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Key Documents

8.20240

Sigma-Aldrich

tert-Butylbenzene

for synthesis

Synonym(s):

tert-Butylbenzene, 2-Methyl-2-phenylpropane

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About This Item

Linear Formula:
(CH3)3CC6H5
CAS Number:
Molecular Weight:
134.22
MDL number:
UNSPSC Code:
12352005
EC Index Number:
202-632-4

Pricing and availability is not currently available.

vapor pressure

1.33 hPa ( 13 °C)

Quality Level

assay

≥99.0% (GC)

form

liquid

autoignition temp.

445 °C

potency

3045 mg/kg LD50, oral (Rat)

expl. lim.

0.8-5.6 % (v/v)

mp

-58 °C

transition temp

flash point 44 °C

solubility

29.5 mg/L

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This Item
WH0003915M1MAB1924MAB1904
antibody form

ascites fluid

antibody form

purified immunoglobulin

antibody form

ascites fluid

antibody form

purified antibody

biological source

mouse

biological source

mouse

biological source

mouse

biological source

rat

Gene Information

human ... LAMC1(3915)

Gene Information

human ... LAMC1(3915)

Gene Information

human ... LAMA2(3908)

Gene Information

mouse ... Lama1(16772)

clone

2E8, monoclonal

clone

2E6-B4, monoclonal

clone

4C7, monoclonal

clone

AL-2, monoclonal

species reactivity

rat, human

species reactivity

human

species reactivity

human

species reactivity

mouse

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

wet ice

Analysis Note

Assay (GC, area%): ≥ 99.0 % (a/a)
Density (d 20 °C/ 4 °C): 0.865 - 0.866
Identity (IR): passes test

pictograms

FlameExclamation mark

signalword

Warning

Hazard Classifications

Flam. Liq. 3 - Skin Irrit. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

116.6 °F - closed cup

flash_point_c

47 °C - closed cup


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Anthony Scott et al.
Acta biochimica et biophysica Sinica, 46(3), 199-203 (2014-01-07)
DNA methylation is an important epigenetic mechanism that ensures correct gene expression and maintains genetic stability. DNA methyltransferase 1 (DNMT1) is the primary enzyme that maintains DNA methylation during replication. Dysregulation of DNMT1 is implicated in a variety of diseases.
Jianqing Lin et al.
The Prostate, 71(4), 333-343 (2010-09-03)
The clinical success of the nucleoside analogs 5-aza-cytidine (5-azaC) and 5-aza-2'deoxycytidine (5-aza-dC) as DNA methyltransferase (DNMT) inhibitors has spurred interest in the development of non-nucleoside inhibitors with improved pharmacologic and safety profiles. Because DNMT catalysis features attack of cytosine bases
Anthony M Chomyk et al.
Scientific reports, 7(1), 8696-8696 (2017-08-20)
Multiple Sclerosis (MS) is an immune-mediated demyelinating disease of the human central nervous system (CNS). Memory impairments and hippocampal demyelination are common features in MS patients. Our previous data have shown that demyelination alters neuronal gene expression in the hippocampus.
Jikui Song et al.
Science (New York, N.Y.), 331(6020), 1036-1040 (2010-12-18)
Maintenance of genomic methylation patterns is mediated primarily by DNA methyltransferase-1 (DNMT1). We have solved structures of mouse and human DNMT1 composed of CXXC, tandem bromo-adjacent homology (BAH1/2), and methyltransferase domains bound to DNA-containing unmethylated CpG sites. The CXXC specifically
Mihika Pradhan et al.
Biochemistry, 47(38), 10000-10009 (2008-08-30)
DNA cytosine methylation is one of the major epigenetic gene silencing marks in the human genome facilitated by DNA methyltransferases. DNA cytosine-5 methyltransferase 1 (DNMT1) performs maintenance methylation in somatic cells. In cancer cells, DNMT1 is responsible for the aberrant

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