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Key Documents

8.52062

Sigma-Aldrich

Fmoc-Tic-OH

Novabiochem®

Synonym(s):

Fmoc-Tic-OH, N-1-Fmoc-L-1,2,3,4,-tetrahydro-isoquinoline-3-carboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C25H21NO4
CAS Number:
136030-33-6
Molecular Weight:
399.44
MDL number:
MFCD00144368
UNSPSC Code:
12352209
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

200

product line

Novabiochem®

assay

≥97.0% (acidimetric)
≥98% (TLC)
≥98.0% (HPLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

Fmoc

storage temp.

15-25°C

SMILES string

N4([C@@H](Cc5c(cccc5)C4)C(=O)[O-])C(=O)OCC1c2c(cccc2)c3c1cccc3

General description

Standard building block for introduction of Tic amino-acid residues by Fmoc SPPS

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS


Literature references

[1] M. Vincent, et al. (1982) Tetrahedron Lett., 16, 1677.
[2] P. L. Julian, et al. (1984) J. Am. Chem. Soc., 79, 180.
[3] W. A. Kazmierski, et al. (1988) Tetrahedron Lett., 44, 697.

Linkage

Replaces: 04-12-1130

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(011C)): ≥ 98 %
Purity (TLC(CMA2)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 97.0 %
Water (K. F.): ≤ 1.00 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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