ABS1073

Anti-Dio3 Antibody

from rabbit, purified by affinity chromatography

• Synonym(s): Type III iodothyronine deiodinase, 5DIII, DIOIII, Type 3 DI, Type-III 5′-deiodinase, Dio3
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: human
• species reactivity (predicted by homology): primate (based on 100% sequence homology)
• technique(s): immunofluorescence: suitable; immunohistochemistry: suitable
• GenBank accession no.: AAB35616
• UniProt accession no.: P55073
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... DIO3(1735)

Description

General description

The enzyme DIO3 is a critical enzyme in thyroid hormone metabolism. It converts the thyroid hormone T4 into the inactive form RT3 and it also converts the thyroid hormone T3 into the inactive form T2. It is thought that DIO3 plays a role in preventing premature exposure of the developing fetus to adult levels of thyroid hormones. DIO3 also regulates the levels of fetal thyroid hormones during gestation, thus DIO3 is critical for proper development and metabolism of the fetus during embryological development. DIO3 is expressed in the placenta and in fetal tissues, and DIO3 is localized to the cell membrane and endosomal membranes. DIO3 is also often expressed in neoplastic tissues and in particular basal cell carcinomas.

Immunogen

BSA-conjugated linear peptide corresponding to the extracellular domain of human Dio3.

Epitope: Extracellular domain

Application

Anti-Dio3 Antibody is an antibody against Dio3 Antibody for use in Immunohistochemistry, Immunofluorescence.

Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected Dio3 in human placenta.
Immunohistochemistry Analysis: A representative lot detected Dio3 in Hepatic tissue (Huang, S.A., et al. (2001). Journal of Clinical Endocrinology & Metabolism. 87(10):4457–4461).
Immunohistochemistry Analysis: A representative lot detected Dio3 in human uterus, placenta, umbilical cord, fetal epithelial, and endometrium (Huang, S.A., et al. (2003). Journal of Clinical Endocrinology & Metabolism. 88(3):1384-1388).

Research Category
Signaling

Research Sub Category
Signaling Neuroscience

Quality

Evaluated by Immunohistochemistry in human uterus tissue.

Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Dio3 in human uterus tissue.

Target description

34 kDa calculated

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to lot specific datasheet.

Legal Information

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Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2