MABE889
Anti-ADAR2 Antibody, clone 1.3.1
clone 1.3.1, from mouse
Synonym(s):
Double-stranded RNA-specific editase 1, RNA-editing deaminase 1, RNA-editing enzyme 1, dsRNA adenosine deaminase
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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General description
Double-stranded RNA-specific editase 1, or RNA-editing deaminase 1, or RNA-editing enzyme 1, or dsRNA adensine deaminase, and encoded by the human gene ADARB1/ ADAR2, DRADA2, RED1 is an enzyme that catalyzes the deamination of adenosine in dsRNA to inosine in a step called A to I RNA editing. This editing alters gene expression by changing codon usage and splicing sites as well as altering general RNA stability. So far the enzyme has been shown to edit and destabilize cancer associated genes as well as functional neurotransmitter receptors, and channel proteins. Interestingly, its activity appears to inhibit cell proliferation and migration in some cells and promote exocytosis and metabolism in others, likely to do differential affects on particular important mRNAs. Highly expressed in brain, heart with lower expression in lung, kidney and liver tissues. Interestingly RNA editing correlates with the grade of malignancy of the tumors, with the high grade tumors showing lower editing is seen.
Immunogen
Epitope: C-terminus
GST-tagged recombinant protein corresponding to the C-terminus of human ADAR2.
Application
Anti-ADAR2 Antibody, clone 1.3.1 detects level of ADAR2 & has been published & validated for use in ADAR2.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Chromatin Biology
Chromatin Biology
Quality
Evaluated by Western Blotting in HeLa nuclear extract.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected ADAR2 in 10 µg of HeLa nuclear extract.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected ADAR2 in 10 µg of HeLa nuclear extract.
Target description
~80 kDa observed
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Christian K Pfaller et al.
PLoS biology, 16(11), e2006577-e2006577 (2018-11-30)
The interferon (IFN)-mediated innate immune response is the first line of defense against viruses. However, an IFN-stimulated gene, the adenosine deaminase acting on RNA 1 (ADAR1), favors the replication of several viruses. ADAR1 binds double-stranded RNA and converts adenosine to
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