MABF73
Anti-Tim3 Antibody, clone 5D12
clone 5D12, from mouse
Synonym(s):
Hepatitis A virus cellular receptor 2 homolog, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell membrane protein 3, TIMD-3, TIM-3
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
General description
As a member of the T cell immunoglobulin and mucin domain (TIM) family, Tim-3 is reported to promote or terminate Th1 immunity and is thought to influence a range of inflammatory conditions. It is constitutively expressed in a subset of murine IFNgamma-secreting Th1 cells, but not Th2 cells, in both human and mice. Additionally, Tim-3 is expressed dendritic cells, and by a subset of CD4+ cells where its levels of expression increase upon anti-CD3/28 stimulation. This molecule is also be highly expressed in in vitro polarized Th1 cells, and at lower levels in Th17 cells. Tim-3 is known to synergize with Toll-like receptors (TLRs) and is thought to regulate Th1 and Th17 cytokine secretion.
Immunogen
Recombinant protein corresponding to full length mouse Tim3.
Application
Anti-Tim3 Antibody, clone 5D12 is an antibody against Tim3 for use in FC.
Research Category
Inflammation & Immunology
Inflammation & Immunology
Research Sub Category
Immunoglobulins & Immunology
Immunoglobulins & Immunology
Quality
Evaluated by Flow Cytometry in RAW264.7 cells.
Flow Cytometry Analysis: A 1:50 dilution of this antibody detected Tim3 in RAW264.7 cells.
Flow Cytometry Analysis: A 1:50 dilution of this antibody detected Tim3 in RAW264.7 cells.
Target description
31 kDa calculated
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
RAW264.7 cells
RAW264.7 cells
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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