MABS2438

Anti-Adiponectin Antibody, clone AD105

• Synonym(s): 30 kDa adipocyte complement-related protein, Adipocyte complement-related 30 kDa protein (ACRP30), Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein, ACDC, ACRP30, APM1,
• UNSPSC Code: 12352203

Properties

• biological source: mouse
• Quality Level: 200
• antibody form: purified antibody
• antibody product type: primary antibodies
• clone: AD105, monoclonal
• mol wt: calculated mol wt 26.41 kDa; observed mol wt ~N/A kDa
• purified by: using protein G
• species reactivity: human
• packaging: antibody small pack of 100
• technique(s): ELISA: suitable
• isotype: IgG1κ
• epitope sequence: Unknown
• Protein ID accession no.: NP_001171271
• UniProt accession no.: Q15848
• storage temp.: 2-8°C
• Gene Information: human ... ADIPOQ(9370)

Description

Specificity

Clone AD105 is a mouse recombinant monoclonal antibody that detects Adiponectin. Suitable for ELISA application paired with Anti-Adiponectin, clone AD72 (MABS2439).

Immunogen

hFc-tagged, full length, human recombinant Adiponectin.

Application

Quality Control Testing

Evaluated by ELISA with hFc-tagged, full length, human recombinant Adiponectin.


Enzyme Immunoassay (ELISA): Various dilutions from a representative lot of this antibody detected recombinant human Adiponectin protein in ELISA application.

Target description

Adiponectin (UniProt: Q15848; also known as 30 kDa adipocyte complement-related protein, Adipocyte complement-related 30 kDa protein (ACRP30), Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein) is encoded by the ADIPOQ (also known as ACDC, ACRP30, APM1, GBP28) gene (Gene ID: 9370) in human. Adiponectin is a homomultimeric secreted glycoprotein, characterized by a collagen-like domain (aa 42-107) and a globular, C1q domain (aa 108-244). It exists in several oligomeric forms, including trimers (low-molecular-weight (LMW)), hexamers, and 12 to 18-mers (high-molecular-weight (HMW)) complexes, with the HMW form being the most biologically active. Adiponectin enhances insulin sensitivity, regulate glucose metabolism, and promote fatty acid oxidation. It activates various signaling pathways, notably the AMP-activated protein kinase (AMPK) pathway, leading to improved metabolic health. Additionally, adiponectin has anti-inflammatory effects and plays a role in cardiovascular health. Adiponectin is expressed in adipose tissue and secreted into the bloodstream. Low levels of adiponectin are linked to obesity, type 2 diabetes, and cardiovascular diseases. Its anti-inflammatory properties suggest a protective role against atherosclerosis and other inflammatory conditions.

Physical form

Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Reconstitution

1 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.

Storage and Stability

Recommended storage: +2°C to +8°C.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.