MABT827-AF555
Anti-Dystrophin Antibody, clone 2C6 (MANDYS106), Alexa Fluor™ 555 Conjugate
clone 2C6 (MANDYS106), from mouse, ALEXA FLUOR™ 555
Synonym(s):
Dystrophin
Sign Into View Organizational & Contract Pricing
Select a Size
All Photos(1)
Select a Size
Change View
About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
Recommended Products
General description
Dystrophin (UniProt P11532) is encoded by the DMD (also known as BMD, CMD3B, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272, MRX85) gene (Gene ID 1756) in human. Dystrophin is localized to the inner part of the muscle fiber cell membrane (sarcolemma), where it forms the dystrophin-associated glycoprotein complex (DGC) that links the extracellular matrix to the actin cytoskeleton. Dystrophin plays an important role in stabilizing the muscle fibre against the mechanical forces of muscle contraction by providing a shock-absorbing connection between the cytoskeleton and the extracellular matrix. Duchenne muscular dystrophy (DMD) is caused by gene mutations that disrupt the open reading frame (ORF) and prevent the full translation of dystrophin. ORF restoration by exon skipping using antisense oligonucleotides targeted to splicing elements are designed to transform the DMD phenotype to that of the milder disorder, Becker muscular dystrophy (BMD), typically caused by in-frame dystrophin deletions that allow the production of an internally deleted but partially functional dystrophin.
Application
The unconjugated antibody (Cat. No. MABT827) and Alexa Fluor™ 488 conjugate (Cat. No. MABT827-AF488) are also available for Immunohistochemistry, Immunofluorescence, and Western Blotting applications.
This mouse monoclonal Anti-Dystrophin Antibody, clone 2C6 (MANDYS106), Alexa Fluor™ 555 Conjugate, Cat. No. MABT827-AF555 is validated for use in Immunofluorescence for the detection of Dystrophin.
Quality
Evaluated by Immunofluorescence in human skeletal muscle tissue sections.
Immunofluorescence Analysis: A 1:100 dilution of this antibody detected dystrophin in human skeletal muscle tissue sections.
Immunofluorescence Analysis: A 1:100 dilution of this antibody detected dystrophin in human skeletal muscle tissue sections.
Target description
~427 kDa observed.
Physical form
Purified mouse IgG2a Alexa Fluor™ 555 conjugate in buffer containing PBS, 1.5% BSA with 0.05% sodium azide
Analysis Note
Control
The unconjugated antibody (Cat. No. MABT827) and Alexa Fluor™ 488 conjugate (Cat. No. MABT827-AF488) are also available for Immunohistochemistry
Immunofluorescence
and Western Blotting applications.
The unconjugated antibody (Cat. No. MABT827) and Alexa Fluor™ 488 conjugate (Cat. No. MABT827-AF488) are also available for Immunohistochemistry
Immunofluorescence
and Western Blotting applications.
Other Notes
Concentration: Please refer to lot specific datasheet.
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
Not finding the right product?
Try our Product Selector Tool.
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service