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MABT827-AF555

Sigma-Aldrich

Anti-Dystrophin Antibody, clone 2C6 (MANDYS106), Alexa Fluor 555 Conjugate

clone 2C6 (MANDYS106), from mouse, ALEXA FLUOR 555

Synonym(s):

Dystrophin

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702

Pricing and availability is not currently available.

biological source

mouse

Quality Level

conjugate

ALEXA FLUOR 555

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2C6 (MANDYS106), monoclonal

species reactivity

human

technique(s)

immunofluorescence: suitable

isotype

IgG2aκ

NCBI accession no.

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BAF187420001HS2134AR0141
material

square white polypropylene

material

polypropylene

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round white polypropylene

material

polypropylene

manufacturer/tradename

Heathrow Scientific HS2132A

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Bel-Art F18742-0001

manufacturer/tradename

Heathrow Scientific HS2134A

manufacturer/tradename

Nalgene® 5974-0404

feature

to hold 16 x 1,5/2.0 mL tubes

feature

Holds 28 x 1.5-2 mL tubes

feature

to hold 20 x 1,5/2.0 mL tubes

feature

Holds 16 x 1-2 mL tubes

packaging

pack of 4 ea

packaging

pack of 1 ea

packaging

pack of 4 ea

packaging

pack of 4 ea

General description

Dystrophin (UniProt P11532) is encoded by the DMD (also known as BMD, CMD3B, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272, MRX85) gene (Gene ID 1756) in human. Dystrophin is localized to the inner part of the muscle fiber cell membrane (sarcolemma), where it forms the dystrophin-associated glycoprotein complex (DGC) that links the extracellular matrix to the actin cytoskeleton. Dystrophin plays an important role in stabilizing the muscle fibre against the mechanical forces of muscle contraction by providing a shock-absorbing connection between the cytoskeleton and the extracellular matrix. Duchenne muscular dystrophy (DMD) is caused by gene mutations that disrupt the open reading frame (ORF) and prevent the full translation of dystrophin. ORF restoration by exon skipping using antisense oligonucleotides targeted to splicing elements are designed to transform the DMD phenotype to that of the milder disorder, Becker muscular dystrophy (BMD), typically caused by in-frame dystrophin deletions that allow the production of an internally deleted but partially functional dystrophin.

Application

The unconjugated antibody (Cat. No. MABT827) and Alexa Fluor 488 conjugate (Cat. No. MABT827-AF488) are also available for Immunohistochemistry, Immunofluorescence, and Western Blotting applications.
This mouse monoclonal Anti-Dystrophin Antibody, clone 2C6 (MANDYS106), Alexa Fluor 555 Conjugate, Cat. No. MABT827-AF555 is validated for use in Immunofluorescence for the detection of Dystrophin.

Quality

Evaluated by Immunofluorescence in human skeletal muscle tissue sections.

Immunofluorescence Analysis: A 1:100 dilution of this antibody detected dystrophin in human skeletal muscle tissue sections.

Target description

~427 kDa observed.

Physical form

Purified mouse IgG2a Alexa Fluor 555 conjugate in buffer containing PBS, 1.5% BSA with 0.05% sodium azide

Analysis Note

Control
The unconjugated antibody (Cat. No. MABT827) and Alexa Fluor 488 conjugate (Cat. No. MABT827-AF488) are also available for Immunohistochemistry

Immunofluorescence

and Western Blotting applications.

Other Notes

Concentration: Please refer to lot specific datasheet.

Legal Information

ALEXA FLUOR is a trademark of Life Technologies

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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P Kielczynski et al.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 46(1), 233-238 (2008-02-02)
In this paper the theoretical analysis and the results of testing of a piezoelectric cantilever for the investigation of material surfaces are presented. The cantilever consists of a thin piezoelectric plate bonded with a thin metal (e.g., molybdenum) foil. The
Charles F Baker et al.
Dalton transactions (Cambridge, England : 2003), (9)(9), 1298-1303 (2004-07-15)
New molybdenum(VI) nitride oxides were synthesised by the reaction of strontium nitride and calcium nitride with molybdenum foil at high temperature in sealed stainless steel crucibles. The reactions yielded single crystalline products determined by X-ray diffraction to form complex structures
J G Watkins et al.
The Review of scientific instruments, 79(10), 10F125-10F125 (2008-12-03)
Two modular arrays of Langmuir probes designed to handle a heat flux of up to 25 MW/m(2) for 10 s exposures have been installed in the lower divertor target plates of the DIII-D tokamak. The 20 pyrolytic graphite probe tips
Michael N Evans
Rapid communications in mass spectrometry : RCM, 22(14), 2211-2219 (2008-06-11)
A reactor for converting cellulose into carbon monoxide for subsequent oxygen isotopic analysis via continuous flow isotope ratio mass spectrometry is described. The system employs an induction heater to produce temperatures >or=1500 degrees C within a molybdenum foil crucible positioned
Dattatray J Late et al.
Nanotechnology, 19(26), 265605-265605 (2008-07-02)
Nanocrystalline lanthanum hexaboride (LaB(6)) films have been deposited on molybdenum foil by the pulsed laser deposition (PLD) technique. The as-deposited films were characterized by x-ray diffraction (XRD), scanning electron microscopy (SEM) and atomic force microscopy (AFM). The XRD pattern shows

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