MABT827-AF555
Anti-Dystrophin Antibody, clone 2C6 (MANDYS106), Alexa Fluor™ 555 Conjugate
clone 2C6 (MANDYS106), from mouse, ALEXA FLUOR™ 555
Synonym(s):
Dystrophin
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
Pricing and availability is not currently available.
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This Item | BAF187420001 | HS2134A | R0141 |
|---|---|---|---|
| material square white polypropylene | material polypropylene | material round white polypropylene | material polypropylene |
| manufacturer/tradename Heathrow Scientific HS2132A | manufacturer/tradename Bel-Art F18742-0001 | manufacturer/tradename Heathrow Scientific HS2134A | manufacturer/tradename Nalgene® 5974-0404 |
| feature to hold 16 x 1,5/2.0 mL tubes | feature Holds 28 x 1.5-2 mL tubes | feature to hold 20 x 1,5/2.0 mL tubes | feature Holds 16 x 1-2 mL tubes |
| packaging pack of 4 ea | packaging pack of 1 ea | packaging pack of 4 ea | packaging pack of 4 ea |
General description
Dystrophin (UniProt P11532) is encoded by the DMD (also known as BMD, CMD3B, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272, MRX85) gene (Gene ID 1756) in human. Dystrophin is localized to the inner part of the muscle fiber cell membrane (sarcolemma), where it forms the dystrophin-associated glycoprotein complex (DGC) that links the extracellular matrix to the actin cytoskeleton. Dystrophin plays an important role in stabilizing the muscle fibre against the mechanical forces of muscle contraction by providing a shock-absorbing connection between the cytoskeleton and the extracellular matrix. Duchenne muscular dystrophy (DMD) is caused by gene mutations that disrupt the open reading frame (ORF) and prevent the full translation of dystrophin. ORF restoration by exon skipping using antisense oligonucleotides targeted to splicing elements are designed to transform the DMD phenotype to that of the milder disorder, Becker muscular dystrophy (BMD), typically caused by in-frame dystrophin deletions that allow the production of an internally deleted but partially functional dystrophin.
Application
The unconjugated antibody (Cat. No. MABT827) and Alexa Fluor™ 488 conjugate (Cat. No. MABT827-AF488) are also available for Immunohistochemistry, Immunofluorescence, and Western Blotting applications.
This mouse monoclonal Anti-Dystrophin Antibody, clone 2C6 (MANDYS106), Alexa Fluor™ 555 Conjugate, Cat. No. MABT827-AF555 is validated for use in Immunofluorescence for the detection of Dystrophin.
Quality
Evaluated by Immunofluorescence in human skeletal muscle tissue sections.
Immunofluorescence Analysis: A 1:100 dilution of this antibody detected dystrophin in human skeletal muscle tissue sections.
Immunofluorescence Analysis: A 1:100 dilution of this antibody detected dystrophin in human skeletal muscle tissue sections.
Target description
~427 kDa observed.
Physical form
Purified mouse IgG2a Alexa Fluor™ 555 conjugate in buffer containing PBS, 1.5% BSA with 0.05% sodium azide
Analysis Note
Control
The unconjugated antibody (Cat. No. MABT827) and Alexa Fluor™ 488 conjugate (Cat. No. MABT827-AF488) are also available for Immunohistochemistry
Immunofluorescence
and Western Blotting applications.
The unconjugated antibody (Cat. No. MABT827) and Alexa Fluor™ 488 conjugate (Cat. No. MABT827-AF488) are also available for Immunohistochemistry
Immunofluorescence
and Western Blotting applications.
Other Notes
Concentration: Please refer to lot specific datasheet.
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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P Kielczynski et al.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 46(1), 233-238 (2008-02-02)
In this paper the theoretical analysis and the results of testing of a piezoelectric cantilever for the investigation of material surfaces are presented. The cantilever consists of a thin piezoelectric plate bonded with a thin metal (e.g., molybdenum) foil. The
Charles F Baker et al.
Dalton transactions (Cambridge, England : 2003), (9)(9), 1298-1303 (2004-07-15)
New molybdenum(VI) nitride oxides were synthesised by the reaction of strontium nitride and calcium nitride with molybdenum foil at high temperature in sealed stainless steel crucibles. The reactions yielded single crystalline products determined by X-ray diffraction to form complex structures
J G Watkins et al.
The Review of scientific instruments, 79(10), 10F125-10F125 (2008-12-03)
Two modular arrays of Langmuir probes designed to handle a heat flux of up to 25 MW/m(2) for 10 s exposures have been installed in the lower divertor target plates of the DIII-D tokamak. The 20 pyrolytic graphite probe tips
Michael N Evans
Rapid communications in mass spectrometry : RCM, 22(14), 2211-2219 (2008-06-11)
A reactor for converting cellulose into carbon monoxide for subsequent oxygen isotopic analysis via continuous flow isotope ratio mass spectrometry is described. The system employs an induction heater to produce temperatures >or=1500 degrees C within a molybdenum foil crucible positioned
Dattatray J Late et al.
Nanotechnology, 19(26), 265605-265605 (2008-07-02)
Nanocrystalline lanthanum hexaboride (LaB(6)) films have been deposited on molybdenum foil by the pulsed laser deposition (PLD) technique. The as-deposited films were characterized by x-ray diffraction (XRD), scanning electron microscopy (SEM) and atomic force microscopy (AFM). The XRD pattern shows
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