11685929001

Guanidine thiocyanate

• Synonym(s): Guanidine thiocyanate, Guanidinium rhodanide, Guanidinium thiocyanate
• Linear Formula: NH₂C(=NH)NH₂ · HSCN
• CAS Number: 593-84-0
• Molecular Weight: 118.16
• Beilstein/REAXYS Number: 3563461
• MDL number: MFCD00013027
• UNSPSC Code: 12352200
• PubChem Substance ID: 329749530

Properties

• form: solid
• mol wt: 118.16
• packaging: pkg of 500 g
• manufacturer/tradename: Roche
• mp: 120-122 °C (lit.)
• absorption: ≤0.10 at 300 and 410 nm in water at 6 M
• shipped in: ambient
• storage temp.: 20-25°C
• SMILES string: SC#N.NC(N)=N
• InChI: 1S/CH5N3.CHNS/c2-1(3)4;2-1-3/h(H5,2,3,4);3H

Description

General description

Guanidine thiocyanate is chaotropic salts which lyse cells and along with nuclease binding matrix it is also seen to inhibit nuclease activity during extraction of DNA. It works as a strong RNase inhibitor in extraction buffers.

Application

Chaotropic agent and strong denaturant; solubilizes cells.

Suitable as denaturing agent for proteins. Guanidine thiocyanate is a stronger denaturant than guanidine hydrochloride.

Suitable as denaturing agent for proteins. Guanidine thiocyanate is a stronger denaturant than guanidine hydrochloride.[1]

Specifications

Absorbance: A₃₀₀ and A₄₁₀ ≤0.10 (6 M in H₂O) each
Formula: CH₅N₃ x HSCN

Physical form

Crystals

Other Notes

For life science research only. Not for use in diagnostic procedures.

Safety Information

• pictograms: GHS05,GHS07
• signalword: Danger
• hcodes: H302 + H312 + H332,H314,H412
• pcodes: P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 4 - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 3 Inhalation - Eye Dam. 1 - Skin Corr. 1C
• supp_hazards: EUH032,EUH071
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable