106232

Trifluoroacetic anhydride

ReagentPlus^®, ≥99%

• Synonym(s): TFAA
• Linear Formula: (CF₃CO)₂O
• CAS Number: 407-25-0
• Molecular Weight: 210.03
• Beilstein/REAXYS Number: 746197
• EC Number: 206-982-9
• MDL number: MFCD00000416
• UNSPSC Code: 12352100
• PubChem Substance ID: 24846727
• NACRES: NA.21
• assay: ≥99%
• bp: 39.5-40 °C (lit.)
• vapor pressure: 6.28 psi ( 20 °C)

Properties

• vapor pressure: 6.28 psi ( 20 °C)
• Quality Level: 100; 200
• product line: ReagentPlus^®
• assay: ≥99%
• dilution: (for general lab use)
• refractive index: n20/D 1.3 (lit.)
• bp: 39.5-40 °C (lit.)
• mp: −65 °C (lit.)
• density: 1.511 g/mL at 20 °C (lit.)
• SMILES string: FC(F)(F)C(=O)OC(=O)C(F)(F)F
• InChI: 1S/C4F6O3/c5-3(6,7)1(11)13-2(12)4(8,9)10
• InChI key: QAEDZJGFFMLHHQ-UHFFFAOYSA-N

Description

Application

For the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for GC analysis. Also used in the oxidation of aldehydes to acids, esters, or amides. Trifluoroacetic anhydride can undergo reaction with deoxyguanosine in pyridine to give the corresponding 6-substituted-2′-deoxyguanosine derivatives. It can also react with urea-hydrogen peroxide complex to generate peroxytrifluoroacetic acid, which can convert aldoximes to nitroalkanes.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS05,GHS07
• signalword: Danger
• hcodes: H314,H332,H412
• pcodes: P261 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A
• supp_hazards: EUH014
• Storage Class: 8B - Non-combustible corrosive hazardous materials
• wgk_germany: WGK 2
• ppe: Faceshields, Gloves, Goggles