40252

N,N-Dimethylformamide diethyl acetal

for esterification of fatty acids, ≥95.0% (GC)

• Synonym(s): 1,1-Diethoxy-N,N-dimethylmethylamine, 1,1-Diethoxytrimethylamine
• Linear Formula: (CH₃)₂NCH(OC₂H₅)₂
• CAS Number: 1188-33-6
• Molecular Weight: 147.22
• Beilstein/REAXYS Number: 741889
• EC Number: 214-707-9
• MDL number: MFCD00009227
• UNSPSC Code: 12352100
• PubChem Substance ID: 329755961
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: ≥95.0% (GC)
• quality: for esterification of fatty acids
• color: colorless to yellow
• refractive index: n20/D 1.397-1.401; n20/D 1.400 (lit.)
• bp: 130-133 °C (lit.)
• density: 0.859 g/mL at 25 °C (lit.)
• functional group: amine; ether
• SMILES string: CCOC(OCC)N(C)C
• InChI: 1S/C7H17NO2/c1-5-9-7(8(3)4)10-6-2/h7H,5-6H2,1-4H3
• InChI key: BWKAYBPLDRWMCJ-UHFFFAOYSA-N

Description

General description

N,N-Dimethylformamide diethyl acetal undergoes Me₃SiCl-mediated three-component coupling reaction with alkyne to yield 2,3,4,5-tetrasubstituted pyridine derivatives.

N,N-Dimethylformamide diethyl acetal (DMF diethyl acetal) on reaction with butanol affords N,N-dimethylformamide dibutyl acetal. It participates in various alkylation, formylation, and aminomethylenation reactions. It has been synthesized from N,N-dialkyl(chloromethylene)ammonium chloride.

Application

N,N-Dimethylformamide diethyl acetal is a suitable reagent for the esterification of fatty acids. It is suitable reagent used in the quantification of cocaine and its primary metabolite, benzoyl ecgonine, from a urine matrix by gas chromatography.

Other Notes

Reagent for the esterification of fatty acids; Review

Safety Information

• pictograms: GHS02
• signalword: Warning
• hcodes: H226
• pcodes: P210 - P370 + P378
• Hazard Classifications: Flam. Liq. 3
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: 82.4 °F - closed cup
• flash_point_c: 28 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter