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49702

Supelco

Carnosol

analytical standard

Synonym(s):

Picrosalvin

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About This Item

Empirical Formula (Hill Notation):
C20H26O4
CAS Number:
5957-80-2
Molecular Weight:
330.42
MDL number:
MFCD02752467
UNSPSC Code:
85151701
PubChem Substance ID:
329757507
NACRES:
NA.24
Pricing and availability is not currently available.

biological source

Rosemarinus officinalis L. leaves

Quality Level

100

grade

analytical standard

assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

storage temp.

−20°C

SMILES string

CC(C)c1cc2[C@@H]3C[C@H]4C(C)(C)CCC[C@]4(C(=O)O3)c2c(O)c1O

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1 of 4

This Item
C9617PHL8015034092
Carnosol analytical standard

49702

Carnosol

Carnosol

C9617

Carnosol

Carnosol phyproof® Reference Substance

PHL80150

Carnosol

Resveratrol analytical standard

34092

Resveratrol

grade

analytical standard

grade

-

grade

primary reference standard

grade

analytical standard

format

neat

format

-

format

neat

format

neat

biological source

Rosemarinus officinalis L. leaves

biological source

Rosemarinus officinalis L.

biological source

-

biological source

-

assay

≥98.0% (HPLC)

assay

-

assay

≥95.0% (HPLC)

assay

-

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable

technique(s)

-

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

General description

Carnosol is a naturally occurring phyto polyphenol[1]or phenolic diterpene[2], found in rosemary, which can show a broad spectrum of applications as a an antioxidant, anticancer agent[2] and anti-inflammatory agent.[3]
Carnosol is one of the phenolic antioxidants present in extracts of the herb rosemary (Rosmarinus officinalis). Carnosol inhibits the formation of tumors derived using irritants such as TPA and DMBA in murine models of carcinogenesis.The effective dose reported is 1-10 μM topically or 6 μg/ml when added to supernatants of cultured cells.Addition of rosemary extracts to the diet as a 1% supplement by weight was also found to decrease the frequency of DMBA-DNA adducts.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

A phenolic diterpene with antioxidant and anticarcinogenic activities.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

This compound is commonly found in plants of the genus: salvia

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCG9960
    BCCF9705
    BCCF3139
    BCCF1273
    BCCD9815

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    Ai-Hsiang Lo et al.
    Carcinogenesis, 23(6), 983-991 (2002-06-26)
    Carnosol is a naturally occurring phytopolyphenol found in rosemary. Carnosol functions as antioxidant and anticarcinogen. In the present study, we compared the antioxidant activity of carnosol and other compounds extracted from rosemary. Carnosol showed potent antioxidative activity in alpha,alpha-diphenyl-beta-picrylhydrazyl (DPPH)
    Carnosol: a promising anti-cancer and anti-inflammatory agent
    Johnson.JJ
    Cancer Letters, 305, 1-7 (2011)
    Shiu-Chen Huang et al.
    Biochemical pharmacology, 69(2), 221-232 (2005-01-04)
    Carnosol, a constant constituent of Rosmarinus officinalis extracts, is a phenolic diterpene shown to have antioxidant and anticarcinogen properties. In our studies, carnosol inhibited the invasion of highly metastatic mouse melanoma B16/F10 cells in vitro. First, the antimetastatic potentials of
    Kai-Cheng Lian et al.
    Toxicology and applied pharmacology, 245(1), 21-35 (2010-02-02)
    The increased adhesion of monocytes to injured endothelial layers is a critical early event in atherogenesis. Under inflammatory conditions, there is increased expression of specific cell adhesion molecules on activated vascular endothelial cells, which increases monocyte adhesion. In our current
    Sang Yong Kim et al.
    Journal of agricultural and food chemistry, 58(3), 1543-1550 (2010-01-16)
    Carnosol, a naturally occurring bioactive phenolic diterpene originating from rosemary and sage, has been shown to exert antioxidant and anti-inflammatory effects. This study examined possible protective effects of carnosol on sodium nitroprusside (SNP)-induced cytotoxicity in C6 glial cells. Carnosol (1-10
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