Skip to Content
MilliporeSigma
All Photos(3)

Key Documents

View All Documentation

P0597

Sigma-Aldrich

Pilocarpine nitrate

meets USP testing specifications

Synonym(s):

Pilocarpine nitrate salt

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

Empirical Formula (Hill Notation):
C11H16N2O2 · HNO3
CAS Number:
148-72-1
Molecular Weight:
271.27
Beilstein/REAXYS Number:
4171406
EC Number:
205-723-7
MDL number:
MFCD00078497
UNSPSC Code:
41116107
PubChem Substance ID:
24898116
NACRES:
NA.21
Pricing and availability is not currently available.

agency

USP/NF
meets USP testing specifications

Quality Level

200

form

crystals

application(s)

pharmaceutical (small molecule)

SMILES string

O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C

InChI

1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1

InChI key

PRZXEPJJHQYOGF-GNAZCLTHSA-N

Gene Information

human ... CHRM1(1128), CHRM3(1131)

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
565788565780565749
β-Secretase inhibitor ≥97% (HPLC), powder

S4562

β-Secretase inhibitor

β-Secretase Inhibitor IV β-Secretase Inhibitor IV, CAS 797035-11-1, is a cell-permeable inhibitor that binds to BACE-1 active site and blocks its proteolytic activity (IC₅₀ = 15 nM for human BACE-1).

565788

β-Secretase Inhibitor IV

β-Secretase Inhibitor III The β-Secretase Inhibitor III controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

565780

β-Secretase Inhibitor III

β-Secretase Inhibitor II The β-Secretase Inhibitor II, also referenced under CAS 263563-09-3, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

565749

β-Secretase Inhibitor II

form

powder

form

solid

form

lyophilized

form

solid

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

mol wt

~_1.65 kDa

mol wt

-

mol wt

-

mol wt

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: soluble

solubility

DMSO: 100 mg/mL

solubility

DMSO: 1 mg/mL

solubility

DMSO: 5 mg/mL

Biochem/physiol Actions

Nonselective muscarinic acetylcholine receptor agonist.
Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.

pictograms

Flame over circleSkull and crossbones
GHS03,GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Ox. Sol. 2

Storage Class

5.1B - Oxidizing hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    SLCJ0525
    SLCC1969
    SLCC1429
    SLCC1435
    SLBX7300

    Don't see the Right Version?

    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

    Search for a COA

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Jungmi Lee et al.
    Analytica chimica acta, 1022, 89-95 (2018-05-08)
    Amyloid-β (Aβ) is generated by proteolytic processing of amyloid precursor protein (APP) by beta-secretase (BACE-1) and gamma-secretase. Amyloid-β is responsible for the formation of senile plaques in Alzheimer's disease (AD). Consequently, inhibition of β-secretase (BACE-1), a rate-limiting enzyme in the
    Hans Hilpert et al.
    Journal of medicinal chemistry, 56(10), 3980-3995 (2013-04-18)
    An extensive fluorine scan of 1,3-oxazines revealed the power of fluorine(s) to lower the pKa and thereby dramatically change the pharmacological profile of this class of BACE1 inhibitors. The CF3 substituted oxazine 89, a potent and highly brain penetrant BACE1
    beta-secretase inhibitor; a promising novel therapeutic drug in Alzheimer?s disease
    Menting KW, et al.
    Frontiers in Aging Neuroscience, 6, 165-165 (2014)
    S Sinha et al.
    Nature, 402(6761), 537-540 (1999-12-11)
    Proteolytic processing of the amyloid precursor protein (APP) generates amyloid beta (Abeta) peptide, which is thought to be causal for the pathology and subsequent cognitive decline in Alzheimer's disease. Cleavage by beta-secretase at the amino terminus of the Abeta peptide
    Patty C Kandalepas et al.
    Acta neuropathologica, 126(3), 329-352 (2013-07-04)
    β-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) is the β-secretase that initiates Aβ production in Alzheimer's disease (AD). BACE1 levels are increased in AD, which could contribute to pathogenesis, yet the mechanism of BACE1 elevation is unclear. Furthermore, the
    View All Related Papers

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service