PHR1078

Phytonadione

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Vitamin K₁, Phytomenadione, 2-Methyl-3-phytyl-1,4-naphthoquinone, 3-Phytylmenadione, Phylloquinone, Vitamin K₁₍₂₀₎
• Empirical Formula (Hill Notation): C₃₁H₄₆O₂
• CAS Number: 84-80-0
• Molecular Weight: 450.70
• Beilstein/REAXYS Number: 2568816
• EC Number: 201-564-2
• MDL number: MFCD00214063
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823101
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• agency: traceable to BP 423; traceable to Ph. Eur. P1609000; traceable to USP 1538006
• API family: phytonadione
• CofA: current certificate can be downloaded
• storage condition: protect from light
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• refractive index: n20/D 1.527 (lit.)
• mp: −20 °C (lit.)
• density: 0.984 g/mL at 25 °C (lit.)

Description

General description

Phytonadione belongs to the category of oral anticonvulsant drugs. It protects a newborn from acquiring hemorrhagic diseases by maintaining a normal blood clotting mechanism.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Phytonadione may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by chromatographic and spectrophotometric techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Values of analytes vary lot to lot.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB3714 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable