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Key Documents

PHR3619

Supelco

Cyclophosphamide Related Compound B

certified reference material, pharmaceutical secondary standard

Synonym(s):

3-(2-Chloroethyl)-2-oxo-2-hydroxy-1,3,6,2-oxadiazaphosphonane

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About This Item

Empirical Formula (Hill Notation):
C7H16ClN2O3P
CAS Number:
Molecular Weight:
242.64
UNSPSC Code:
41116107
NACRES:
NA.24

Pricing and availability is not currently available.

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to USP 1157024

CofA

current certificate can be downloaded

packaging

pkg of 50 mg

application(s)

pharmaceutical

SMILES string

[P]1(=O)(N(CCNCCCO1)CCCl)O

InChI

1S/C7H16ClN2O3P/c8-2-5-10-6-4-9-3-1-7-13-14(10,11)12/h9H,1-7H2,(H,11,12)

InChI key

SIMWMEHPUXRDQD-UHFFFAOYSA-N

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1 of 4

This Item
SAB4700979HPA000764AB10428
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

-

biological source

rabbit

biological source

mouse

biological source

rabbit

biological source

rabbit

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

saturated ammonium sulfate (SAS) precipitated

UniProt accession no.

P07288

UniProt accession no.

-

UniProt accession no.

P07288

UniProt accession no.

P07288

Gene Information

human ... KLK3(354)

Gene Information

human ... KLK3(354)

Gene Information

human ... KLK3(354)

Gene Information

human ... KLK3(354)

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA6959(changes by product) in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Certificates of Analysis (COA)

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Single-nucleotide polymorphism rs1058205 of KLK3 is associated with the risk of prostate cancer: A case-control study of Han Chinese men in Northeast China.
Chen C and Xin Z
Medicine, 96(10) (2017)
Keke Zhang et al.
Molecular medicine reports, 17(6), 8203-8211 (2018-04-17)
The androgen receptor (AR) has a crucial role in prostate cancer. RNA‑binding protein‑mediated post‑transcriptional regulation is important in the initiation and development of cancer. The present study attempted to elucidate the mutual association of AR and RNA‑binding protein quaking (QKI)
Eric G Bluemn et al.
Cancer cell, 32(4), 474-489 (2017-10-11)
Androgen receptor (AR) signaling is a distinctive feature of prostate carcinoma (PC) and represents the major therapeutic target for treating metastatic prostate cancer (mPC). Though highly effective, AR antagonism can produce tumors that bypass a functional requirement for AR, often
Pavlo L Kovalenko et al.
The Journal of surgical research, 190(1), 177-184 (2014-04-29)
Schlafen proteins have previously been linked to leukocyte and intestinal epithelial differentiation. We hypothesized that Schlafen 12 (SLFN12) overexpression in human prostate epithelial cells would modulate expression of prostate-specific antigen (PSA) and dipeptidyl peptidase 4 (DPP4), markers of prostatic epithelial
Seung-Yon Lee et al.
Cancer letters, 354(2), 390-397 (2014-09-10)
Metformin, a diabetes drug, has been reported to inhibit the growth of prostate cancer cells. In this study, we investigated the effect and action mechanism of metformin on the function of androgen receptor (AR), a key molecule in the proliferation

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