SMB01318

3-Hydroxydesloratadine

• Synonym(s): 3-Hydroxy Desloratadine, Desloratadine 3-Hydroxy Impurity
• Empirical Formula (Hill Notation): C₁₉H₁₉ClN₂O
• CAS Number: 119410-08-1
• Molecular Weight: 326.82
• MDL number: MFCD00878381
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• description: Modulation and Signaling
• Quality Level: 100
• assay: ≥90%
• form: solid
• technique(s): HPLC: suitable
• color: pale yellow to off-white
• storage temp.: −20°C
• SMILES string: Clc1cc2c(cc1)C(=C4CCNCC4)c3ncc(cc3CC2)O
• InChI: 1S/C19H19ClN2O/c20-15-3-4-17-13(9-15)1-2-14-10-16(23)11-22-19(14)18(17)12-5-7-21-8-6-12/h3-4,9-11,21,23H,1-2,5-8H2
• InChI key: NDFMTPISBHBIKE-UHFFFAOYSA-N

Description

General description

3-hydroxy Desloratadine is a major metabolite of desloratadine and loratadine, which are non-sedating tricyclic antagonists of the histamine H1 receptor and antihistamine drugs used to manage allergic rhinitis and chronic idiopathic urticaria.

Application

3-Hydroxy Desloratadine finds application in metabolomics and drug discovery research

Biochem/physiol Actions

3-hydroxydesloratadine formation involves the oxidation of desloratadine by cytochrome P450 (CYP2C8) and subsequent glucuronidation by UDP-glucuronosyltransferase UGT2B10 in cryopreserved human hepatocytes. This pathway leads to the production of 3-hydroxydesloratadine, a major active human metabolite.

Features and Benefits

• High quality compound suitable for multiple research applications
• Compatible with a wide variety of chromatographic and spectrometry techniques

Other Notes

For additional information on our range of Biochemicals, please complete this form.

This product is intended for research purposes only, and it is not meant for human consumption.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable