159417

Hydroxylamine hydrochloride

ReagentPlus^®, 99%

• Synonym(s): Hydroxylammonium chloride
• Linear Formula: NH₂OH · HCl
• CAS Number: 5470-11-1
• Molecular Weight: 69.49
• Beilstein/REAXYS Number: 3539763
• EC Number: 226-798-2
• MDL number: MFCD00051089
• UNSPSC Code: 12352300
• PubChem Substance ID: 329751008
• NACRES: NA.21
• assay: 99%
• form: crystalline

Properties

• vapor pressure: 0.001 hPa ( 50 °C)
• Quality Level: 100
• product line: ReagentPlus^®
• assay: 99%
• form: crystalline
• technique(s): inhibition assay: suitable
• pH: 2.5-3.5 (20 °C, 50 g/L)
• mp: 155-157 °C (dec.) (lit.)
• density: 1.67 g/mL at 25 °C (lit.)
• SMILES string: Cl.NO
• InChI: 1S/ClH.H3NO/c;1-2/h1H;2H,1H2
• InChI key: WTDHULULXKLSOZ-UHFFFAOYSA-N

Description

General description

Hydroxylamine hydrochloride (Hydroxylammonium chloride) participates in the synthesis of 1,2,4-oxadiazoles, secondary amides and tertiary amides.

Hydroxylamine hydrochloride (NH₂OH.HCl) is a hygroscopic salt widely used as a reactant in electrophilic substitution reactions, oxidation, and reduction reactions. It is also used in the synthesis of nitriles, pyrazoles, isoxazoles, nitrones, and pyridine.

Application

Hydroxylamine hydrochloride can be used as a reactant:

• in the synthesis of primary amides from aldehydes in the presence of cesium carbonate (Cs₂CO₃) as a catalyst.
• in the conversion of alicyclic /aliphatic carbonyl compounds and the aromatic aldehydes into corresponding oximes.
• in the one-pot synthesis of nitriles from aldehydes in the presence of sodium sulfate (anhyd) and sodium bicarbonate catalysts.
• It can also be used as a reducing agent in the preparation of single-layer reduced graphene oxide (RGO) sheets and films.

Biochem/physiol Actions

MAO inhibitor; inhibits platelet aggregation.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS08,GHS05,GHS07,GHS09
• signalword: Warning
• hcodes: H290,H302 + H312,H315,H317,H319,H351,H373,H410
• pcodes: P273 - P280 - P301 + P312 - P302 + P352 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Carc. 2 - Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral
• target_organs: spleen
• Storage Class: 4.1A - Other explosive hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable