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22244

Sigma-Aldrich

Ceramide from bovine spinal cord

≥98.0% (TLC)

Synonym(s):

Bovine Spinal Cord Ceramide

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About This Item

MDL number:
MFCD00146359
UNSPSC Code:
12352211
NACRES:
NA.25
Pricing and availability is not currently available.

biological source

bovine spinal cord

Quality Level

100

assay

≥98.0% (TLC)

form

solid

impurities

α-hydroxy fatty acids

solubility

chloroform/methanol (99:1): 20 mg/mL, clear, colorless

lipid type

sphingolipids

shipped in

wet ice

storage temp.

−20°C

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PHR2684PHR3299PHR3457
Cyclobenzaprine Hydrochloride certified reference material, pharmaceutical secondary standard

PHR2797

Cyclobenzaprine Hydrochloride

Cyproheptadine Hydrochloride pharmaceutical secondary standard, certified reference material

PHR2684

Cyproheptadine Hydrochloride

Cyclobenzaprine Related Compound A certified reference material, pharmaceutical secondary standard

PHR3299

Cyclobenzaprine Related Compound A

Levalbuterol hydrochloride certified reference material, pharmaceutical secondary standard

PHR3457

Levalbuterol hydrochloride

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. C3200000, traceable to BP BP886, traceable to USP 1154503

agency

traceable to Ph. Eur. C3280000, traceable to USP 1161000

agency

traceable to USP 1154514

agency

traceable to USP 1358784

description

Pharmaceutical Secondary Standard; Certified Reference Material

description

-

description

-

description

-

API family

cyclobenzaprine

API family

cyproheptadine

API family

-

API family

-

form

solid

form

solid

form

-

form

-

Application

Ceramide is used to investigate effects on programmed cell death (apoptosis) and insulin signaling.

Biochem/physiol Actions

Ceramide is a minor component of cell membranes. Activates atypical protein kinase C (e.g., PKCzeta) [1].

Preparation Note

from cerebrosides by a modification of the procedure by H.E. Carter et al., J. Lipid Res. 2, 228 (1961)

Other Notes

Sales restrictions may apply

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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    Certificates of Analysis (COA)

    Lot/Batch Number
    SLCL1004
    SLCH6735
    SLCF0412
    SLBX4561
    SLBS2960V

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    Darren J Powell et al.
    Molecular and cellular biology, 23(21), 7794-7808 (2003-10-16)
    Ceramide is generated in response to numerous stress-inducing stimuli and has been implicated in the regulation of diverse cellular responses, including cell death, differentiation, and insulin sensitivity. Recent evidence indicates that ceramide may regulate these responses by inhibiting the stimulus-mediated
    M G Yefimova et al.
    Human reproduction (Oxford, England), 35(6), 1346-1362 (2020-06-13)
    Do human granulosa cells (GCs) ingest and destroy apoptotic oocytes? Somatic GCs ingest and destroy apoptotic oocytes and other apoptotic substrates through unconventional autophagy-assisted phagocytosis. Most (99%) ovarian germ cells undergo apoptosis through follicular atresia. The mode of cleaning of
    Marta Pera et al.
    The EMBO journal, 36(22), 3356-3371 (2017-10-12)
    In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by β-secretase to generate a 99-aa C-terminal fragment (C99) that is then cleaved by γ-secretase to generate the β-amyloid (Aβ) found in senile plaques.

    Articles

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    Oxidative stress is mediated, in part, by reactive oxygen species produced by multiple cellular processes and controlled by cellular antioxidant mechanisms such as enzymatic scavengers or antioxidant modulators. Free radicals, such as reactive oxygen species, cause cellular damage via cellular.

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