29311

CHES

BioUltra, ≥99.5% (T)

• Synonym(s): 2-(Cyclohexylamino)ethanesulfonic acid
• Empirical Formula (Hill Notation): C₈H₁₇NO₃S
• CAS Number: 103-47-9
• Molecular Weight: 207.29
• Beilstein/REAXYS Number: 2967601
• EC Number: 203-115-6
• MDL number: MFCD00003835
• UNSPSC Code: 12161700
• PubChem Substance ID: 57648360
• NACRES: NA.25

Properties

• product line: BioUltra
• Quality Level: 200
• assay: ≥99.5% (T)
• form: powder
• impurities: insoluble matter, passes filter test
• ign. residue: ≤0.05%
• loss: ≤0.5% loss on drying, 110 °C
• pH: 3.0-5.0 (25 °C, 0.5 M in H₂O)
• useful pH range: 8.6-10.0
• pKa (25 °C): 9.3

Description

General description

Cyclohexylaminoethanesulfonic acid (CHES) is a buffering agent. Its structure contains a hydrophilic taurine (2-aminoethanesulfonic acid) moiety and a hydrophobic cyclohexyl group. CHES binds to the active site of several enzymes and inhibits substrate binding and enzymatic activity. Therefore, CHES may be used as a scaffold for new drug development for regulating enzyme activity.

Application

2-(Cyclohexylamino)ethanesulfonic acid (CHES) has been used in the preparation of dimethyl trisulfide- polysorbate 80 (DMTS-PS80) formulation.

Other Notes

Buffer for studying pH-dependent processes in enzymology;citation Has a high affinity for the iodoacetate binding site of liver alcohol dehydrogenase.citation

Buffer for studying pH-dependent processes in enzymology; Has a high affinity for the iodoacetate binding site of liver alcohol dehydrogenase.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves