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36105

Sigma-Aldrich

(±)-Sodium β-hydroxyisobutyrate

≥96.0%

Synonym(s):

β-Hydroxyisobutyric acid sodium salt, (±)-β-HIBA-Na, 3-Hydroxy-2-methylpropionic acid sodium salt, Sodium 3-hydroxy-2-methylpropionate

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About This Item

Empirical Formula (Hill Notation):
C4H7NaO3
CAS Number:
1219589-99-7
Molecular Weight:
126.09
MDL number:
MFCD16875405
UNSPSC Code:
12352106
PubChem Substance ID:
329755270
NACRES:
NA.25
Pricing and availability is not currently available.

Quality Level

100

assay

≥96.0% (GC)
≥96.0%

form

powder

composition

sodium, 17.5-19.0%

storage temp.

2-8°C

SMILES string

[Na+].CC(CO)C([O-])=O

InChI

1S/C4H8O3.Na/c1-3(2-5)4(6)7;/h3,5H,2H2,1H3,(H,6,7);/q;+1/p-1

InChI key

RBJZIQZDAZLXEK-UHFFFAOYSA-M

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Show Differences

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This Item
SAB1307082SAB5700869SAB5701092
Anti-USP7/HAUSP antibody produced in rabbit

SAB5701448

Anti-USP7/HAUSP antibody produced in rabbit

ANTI-USP7 (HAUSP)(C-TERMINAL) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution

SAB1307082

ANTI-USP7 (HAUSP)(C-TERMINAL) antibody produced in rabbit

Anti-DUSP6 antibody produced in rabbit

SAB5700869

Anti-DUSP6 antibody produced in rabbit

Anti- DRP1 antibody produced in rabbit

SAB5701092

Anti- DRP1 antibody produced in rabbit

clone

monoclonal

clone

polyclonal

clone

monoclonal

clone

polyclonal

species reactivity

mouse, rat, human

species reactivity

human

species reactivity

mouse, rat, human

species reactivity

mouse, human, rat

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

Gene Information

human ... USP7(7874)

Gene Information

human ... USP7(7874)

Gene Information

human ... DUSP6(1848)

Gene Information

human ... DNM1L(10059)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

UniProt accession no.

Q93009

UniProt accession no.

Q93009

UniProt accession no.

Q16828

UniProt accession no.

O00429

Application

3-Hydroxyisobutyrate (HIBA) may be used to study the distribution, characterization and kinetics of enzymes involved in branched chain amino acid metabolism such as 3-hydroxyisobutyrate dehydrogenase (EC: 1.1.1.31) and 3-hydroxyisobutyryl-CoA hydrolase (EC: 3.1.2.4).

Biochem/physiol Actions

3-Hydroxyisobutyrate (HIBA), is formed in the valine catabolism[1], it is a reactant of enzyme 3-hydroxyisobutyrate dehydrogenase (EC: 1.1.1.31) and 3-hydroxyisobutyryl-CoA hydrolase (EC: 3.1.2.4); it was found to have increased concentrations in MS patient metabolic profiles[2].

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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    BCCB9838
    BCBW6426
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    BCBT9730

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    Norbert W Lutz et al.
    Biochemical and biophysical research communications, 354(1), 160-164 (2007-01-16)
    (1)H NMR spectroscopy of cerebrospinal fluid (CSF) is currently being used to study metabolic profiles characteristic of distinct multiple sclerosis (MS) manifestations. For select MS patient groups, we have previously detected significantly increased concentrations of several identified metabolites and one
    Mammalian 3-hydroxyisobutyrate dehydrogenase.
    J W Hawes et al.
    Methods in enzymology, 324, 218-228 (2000-09-16)
    Disorders of the metabolism of amino acids and related compounds.
    Shih, V. E. and Mandell, R. et al.
    Genetic Disorders and the Fetus, 514-553 (2010)
    Tianran Yao et al.
    Applied biochemistry and biotechnology, 160(3), 694-703 (2009-06-12)
    The MmsB gene product from Bacillus cereus ATCC14579 exhibits 3-hydroxypropionate dehydrogenase activity. It encodes the 32-kDa enzyme protein composed of 292 amino acids. Recombinant 3-hydroxyisobutyrate dehydrogenase (3-HIBADH) was purified 100-fold from cell extract by ammonium sulfate fractionation and column chromatography.
    Radovan Murín et al.
    Journal of neurochemistry, 105(4), 1176-1186 (2008-02-21)
    The branched-chain amino acids (BCAAs)--isoleucine, leucine, and valine--belong to the limited group of substances transported through the blood-brain barrier. One of the functions they are thought to have in brain is to serve as substrates for meeting parenchymal energy demands.
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