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Key Documents

AV34800

Sigma-Aldrich

Anti-TRIM38 (AB1) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-Tripartite motif-containing 38

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

53 kDa

species reactivity

human

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_006346

UniProt accession no.

O00635

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TRIM38(10475)

General description

TRIM38 is a tripartite motif protein that inhibits Toll-like receptor 3 (TLR3)-mediated type I interferon signaling and NF-κB activation.
Rabbit Anti-TRIM38 antibody recognizes human TRIM38.

Immunogen

Synthetic peptide directed towards the middle region of human TRIM38

Application

Rabbit Anti-TRIM38 antibody is suitable for western blot applications at a concentration of 0.5 μg/ml.

Biochem/physiol Actions

TRIM38 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified.The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified.

Sequence

Synthetic peptide located within the following region: SPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNNAKSSDKEEKHRK

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
QC7799

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Ming-Ming Hu et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(4), 1509-1514 (2014-01-18)
TNFα and IL-1β are two proinflammatory cytokines that play critical roles in many diseases, including rheumatoid arthritis and infectious diseases. How TNFα- and IL-1β-mediated signaling is finely tuned is not fully elucidated. Here, we identify tripartite-motif protein 38 (TRIM38) as

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