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Key Documents

AV43937

Sigma-Aldrich

Anti-SLC25A24 antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-APC1, Anti-DKFZp586G0123, Anti-RP11-356N1.3, Anti-SCAMC-1, Anti-Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

45 kDa

species reactivity

dog, horse, guinea pig, rat, mouse, bovine, human

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_037518

UniProt accession no.

Q6NUK1

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... SLC25A24(29957)

Immunogen

Synthetic peptide directed towards the middle region of human SLC25A24

Application

Anti-SLC25A24 antibody produced in rabbit is suitable for western blotting at a concentration of 2.5μg/ml.

Biochem/physiol Actions

SLC25A24 (APC1) is a short calcium-binding mitochondrial carrier (SCaMC) that exchanges phosphate ATP-Mg for phosphate across the inner mitochondrial membrane. Altered expression of gene encoding APC1 has been reported in autism spectrum disorders.

Sequence

Synthetic peptide located within the following region: FLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLLA

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
QC17591

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Ayyappan Anitha et al.
Molecular autism, 3(1), 12-12 (2012-11-03)
Mitochondrial dysfunction (MtD) has been observed in approximately five percent of children with autism spectrum disorders (ASD). MtD could impair highly energy-dependent processes such as neurodevelopment, thereby contributing to autism. Most of the previous studies of MtD in autism have
Araceli del Arco et al.
The Journal of biological chemistry, 279(23), 24701-24713 (2004-04-01)
Aralar1 and citrin were identified as calcium binding aspartate/glutamate carriers (AGC) in mitochondria. The presence of calcium binding motifs facing the extramitochondrial space allows the regulation of the transport activity of these carriers by cytosolic calcium and provides a new

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