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B016

Sigma-Aldrich

Benoxathian hydrochloride

solid

Synonym(s):

2-[[[2-(2,6-Dimethoxyphenoxy)ethyl]-amino]-methyl]-1,4-benzoxathian hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H23NO4S · HCl
CAS Number:
92642-97-2
Molecular Weight:
397.92
MDL number:
MFCD00055188
UNSPSC Code:
12352202
PubChem Substance ID:
24277758
NACRES:
NA.77
Pricing and availability is not currently available.

form

solid

Quality Level

100

color

white

solubility

H2O: soluble (Aqueous solutions may be stored for several weeks at -20 °C.)
ethanol: soluble
isopropanol: soluble

SMILES string

Cl.COc1cccc(OC)c1OCCNCC2CSc3ccccc3O2

InChI

1S/C19H23NO4S.ClH/c1-21-16-7-5-8-17(22-2)19(16)23-11-10-20-12-14-13-25-18-9-4-3-6-15(18)24-14;/h3-9,14,20H,10-13H2,1-2H3;1H

InChI key

OWRADFDDJVNMGL-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

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1 of 4

This Item
EHU023791EHU025581EHU032101
MISSION® esiRNA targeting human MAPRE1

EHU045671

MISSION® esiRNA

MISSION® esiRNA targeting human CD93

EHU023791

MISSION® esiRNA

MISSION® esiRNA targeting human MYH15

EHU025581

MISSION® esiRNA

MISSION® esiRNA targeting human NCBP2

EHU032101

MISSION® esiRNA

esiRNA cDNA target sequence

TTCGGAAAGCTACGGAACATTGAATTGATTTGCCAGGAGAACGAGGGGGAAAACGACCCTGTATTGCAGAGGATTGTAGACATTCTGTATGCCACAGATGAAGGCTTTGTGATACCTGATGAAGGGGGCCCACAGGAGGAGCAAGAAGAGTATTAACAGCCTGGACCAGCAGAGCAACATCGGAATTCTTCACTCCAAATCATGTGCTTAACTGTAAAATACTCCCTTTTGTTATCCTTAGAGGACTCACTGGTTTCTTTTCATAAGCAAAAAGTACCTCTTCTTAAAGTGCACTTTGCAGACGTTTCACTCCTTTTCCAATAAGTTTGAGTTAGGAGCTTTTACCTTGTAGCAGAGCAGTATTAACACCTAGTTGGTTCACCTGGAAAACAGAGAGGCTGACCG

esiRNA cDNA target sequence

CTGGGGCTACTGGTCTATCGCAAGCGGAGAGCGAAGAGGGAGGAGAAGAAGGAGAAGAAGCCCCAGAATGCGGCAGACAGTTACTCCTGGGTTCCAGAGCGAGCTGAGAGCAGGGCCATGGAGAACCAGTACAGTCCGACACCTGGGACAGACTGCTGAAAGTGAGGTGGCCCTAGAGACACTAGAGTCACCAGCCACCATCCTCAGAGCTTTGAACTCCCCATTCCAAAGGGGCACCCACATTTTTTTGAAAGACTGGACTGGAATCTTAGCAAACAATTGTAAGTCTCCTCCTTAAAGGCCCCTTGGAACATGCAGGTATTTTCTACGGGTGTTTGATGTTCCTGAAGTGGAAGCTGTGTGTTGGCGTGCCACGGTGGGGATTTCGTGACTCTATAATGATTGTTACTCCCCCTCCCTTT

esiRNA cDNA target sequence

GGCCAACTGGAAGCAATAAGAGATGAGAGACTATCTAAAGTCTTCACATTGTTCCAAGCCAGAGCACAGGGCAAACTGATGCGAATCAAATTCCAGAAGATTCTGGAAGAAAGGGATGCACTTATTTTGATCCAATGGAACATAAGAGCTTTCATGGCTGTGAAGAACTGGCCCTGGATGAGGCTCTTCTTCAAGATCAAGCCTCTTGTTAAATCTTCAGAAGTAGGAGAAGAAGTAGCTGGACTGAAGGAAGAGTGTGCACAATTACAGAAAGCCTTGGAGAAATCAGAGTTTCAGAGGGAGGAACTGAAAGCAAAGCAAGTATCCCTCACTCAGGAAAAAAATGACCTGATTCTTCAGCTTCAGGCTGAGCAAGAGACACTGGCAAATGTTGAAGAGCAGTGCGAGTGGCTGATTAA

esiRNA cDNA target sequence

GGAATATTACTCACGCGCAGATGCGGAAAACGCCATGCGGTACATAAATGGGACGCGTCTGGATGACCGAATCATTCGCACAGACTGGGACGCAGGCTTTAAGGAGGGCAGGCAATACGGCCGTGGGCGATCTGGGGGCCAGGTTCGGGATGAGTATCGGCAGGACTACGATGCTGGGAGAGGAGGCTATGGAAAACTGGCACAGAACCAGTGAGTGGTGAGAGCTCTGTCAGTGACAAACACTCCTTTGGCCTGTTGAATTTGCTGAAGAACATCACCTAAAGTCTGCACACGAGCCCATTTTTACCAAGATTTGATCAGTGTCTTTACTGAGCTGGAAGCCTCTGAAAGTTATTAAAGGACAGAATCCAAAAGAATGCCTTTAATTCTTGTCTGAGAATCTTGGCCATGTG

Ensembl | human accession no.

ENSG00000101367

Ensembl | human accession no.

ENSG00000125810

Ensembl | human accession no.

ENSG00000144821

Ensembl | human accession no.

ENSG00000114503

Gene Information

human ... MAPRE1(22919), MAPRE1(22919)

Gene Information

human ... CD93(22918), CD93(22918)

Gene Information

human ... MYH15(22989), MYH15(22989)

Gene Information

human ... NCBP2(22916), NCBP2(22916)

product line

MISSION®

product line

MISSION®

product line

MISSION®

product line

MISSION®

NCBI accession no.

NM_012325

NCBI accession no.

NM_012072

NCBI accession no.

NM_014981

NCBI accession no.

NM_007362

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Biochem/physiol Actions

Selective α1-adrenoceptor antagonist.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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    117H46572
    117H4657

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    C H Brown et al.
    The Journal of physiology, 507 ( Pt 3), 831-842 (1998-05-23)
    1. We have tested the hypothesis that morphine withdrawal excitation of oxytocin neurones that follows from administration of naloxone to morphine-dependent rats is a consequence of excitation of noradrenergic neurones. 2. Female rats were made morphine dependent by intracerebroventricular (i.c.v.)
    S Ma et al.
    Journal of neuroendocrinology, 17(11), 761-769 (2005-10-13)
    Chronic intermittent cold stress sensitises activation of the hypothalamic-pituitary-adrenal (HPA) axis by novel acute stress. We have shown that enhanced noradrenergic function in limbic forebrain contributes to HPA sensitisation. In the present study, we investigated whether chronic intermittent cold also
    Jessica A Cardin et al.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(35), 7745-7753 (2004-09-03)
    Norepinephrine (NE) plays a complex role in the behavioral state-dependent regulation of sensory processing. However, the role of forebrain NE action in modulating high-order sensory activity has not been directly addressed. In this study, we take advantage of the discrete
    Derek Lupinsky et al.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(22), 7624-7633 (2010-06-04)
    While stressors are known to increase medial prefrontal cortex (PFC) glutamate (GLU) levels, the mechanism(s) subserving this response remain to be elucidated. We used microdialysis and local drug applications to investigate, in male Long-Evans rats, whether the PFC GLU stress
    S Ma et al.
    Journal of neuroendocrinology, 17(1), 22-28 (2005-02-22)
    Activation of the brain noradrenergic system during stress plays an important integrative function in coping and stress adaptation by facilitating transmission in many brain regions involved in regulating behavioural and physiological components of the stress response. The medial amygdala (MeA)
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