B2682

Boc-Asp(OMe)-fluoromethyl ketone

≥90% (TLC), solid

• Synonym(s): Boc-D-FMK
• Empirical Formula (Hill Notation): C₁₁H₁₈NO₅F
• CAS Number: 187389-53-3
• Molecular Weight: 263.26
• MDL number: MFCD03453073
• UNSPSC Code: 12352209
• PubChem Substance ID: 329773206
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥90% (TLC)
• form: solid
• solubility: DMF: soluble
• storage temp.: −20°C
• SMILES string: COC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)CF
• InChI: 1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)/t7-/m0/s1
• InChI key: MXOOUCRHWJYCAL-ZETCQYMHSA-N

Description

Application

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice , as a protease inhibitor to study its effects on cell death in parasites .

Biochem/physiol Actions

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) permits cell permeability. It is a caspase inhibitor and suppresses apoptosis induced by various kinds of stimuli. Boc-D-fmk poorly inhibits caspases-2, -5, -6 and -10.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)