B9934

BTA-1

≥98% (HPLC), solid

• Synonym(s): 2-(4´-Methylaminophenyl)benzothiazole
• Empirical Formula (Hill Notation): C₁₄H₁₂N₂S
• CAS Number: 439858-28-3
• Molecular Weight: 240.32
• MDL number: MFCD04974146
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724428
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• color: yellow
• solubility: DMSO: soluble ~10 mg/mL
• storage temp.: 2-8°C
• SMILES string: CNc1ccc(cc1)-c2nc3ccccc3s2
• InChI: 1S/C14H12N2S/c1-15-11-8-6-10(7-9-11)14-16-12-4-2-3-5-13(12)17-14/h2-9,15H,1H3
• InChI key: FHJRKGXJBXPBGA-UHFFFAOYSA-N
• Gene Information: human ... APP(351)

Description

Biochem/physiol Actions

BTA-1 is a fluorescent thioflavin-T derivative with 50-fold higher affinity for β-amyloid aggregates.

BTA-1 is a probe for β-amyloid aggregates; fluorescent thioflavin-T derivative; exhibits high affinity for amyloid deposits; displays 50-fold higher affinity than thioflavin-T; selectively stains cerebral plaques and cerebrovascular amyloid deposits in the brains of PS1/APP transgenic mice, as well as Aβ fibrils in postmortem brain tissue obtained from AD patients; crosses the blood brain barrier.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)