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C0166

Sigma-Aldrich

Cys-Gly

≥85% (TLC), suitable fo HPLC

Synonym(s):

L-cysteinyl-glycine

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About This Item

Empirical Formula (Hill Notation):
C5H10N2O3S
CAS Number:
19246-18-5
Molecular Weight:
178.21
MDL number:
MFCD00055567
UNSPSC Code:
12352209
PubChem Substance ID:
24892240
NACRES:
NA.26
Pricing and availability is not currently available.

Product Name

Cys-Gly, ≥85% (TLC)

Quality Level

200

assay

≥85% (TLC)

form

solid

technique(s)

HPLC: suitable

storage temp.

−20°C

SMILES string

NC(CS)C(=O)NCC(O)=O

InChI

1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)

InChI key

ZUKPVRWZDMRIEO-UHFFFAOYSA-N

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Y0001567PHR2728BP133
Docusate sodium meets USP testing specifications

D1685

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Docusate sodium European Pharmacopoeia (EP) Reference Standard

Y0001567

Docusate sodium

Docusate Sodium certified reference material, pharmaceutical secondary standard

PHR2728

Docusate Sodium

Docusate sodium British Pharmacopoeia (BP) Reference Standard

BP133

Docusate sodium

technique(s)

protein quantification: suitable

technique(s)

-

technique(s)

-

technique(s)

-

form

solid

form

-

form

solid

form

waxy solid

application(s)

detection
pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical small molecule

application(s)

pharmaceutical
pharmaceutical small molecule

Quality Level

200

Quality Level

-

Quality Level

300

Quality Level

-

description

anionic

description

-

description

Pharmaceutical Secondary Standard; Certified Reference Material

description

-

General description

Cys-Gly, a dipeptide is a catabolic byproduct of glutathione. [1]

Application

Cys-Gly has been used for derivatization by p-hydroxymercury benzoate (PHMB) for calibration of reversed phase chromatography coupled on-line and sequentially with a UV−visible diode array detector (RPLC-DAD).[2]

Biochem/physiol Actions

Cys-Gly is a precursor for glutathione biosynthesis in the neurons.[3] It favors reactive oxygen species generation in the presence of transition metal ions. A normal level of cys-gly is essential for normal cellular function.[1]
L-Cysteine-L-Glycine (Cys-Gly) is used in studies on the homeostasis of glutathione. Cys-Gly is an important molecule for study in the areas of thiol homeostasis, oxidative stress and metals management.

Other Notes

Glutathione fragment

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCG4571
    BCCD1140
    BCCB4755
    BCBW8926
    BCBT7820

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    Sara Trevisan et al.
    Physiologia plantarum, 166(3), 794-811 (2018-09-22)
    Nitrogen (N) is an indispensable nutrient for crops but its availability in agricultural soils is subject to considerable fluctuation. Plants have developed plastic responses to external N fluctuations in order to optimise their development. The coordinated action of nitric oxide
    Rafał Głowacki et al.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(28), 3400-3404 (2009-06-30)
    A fully automated HPLC method for the simultaneous determination of total thiols in plasma samples has been developed. The method involves reductive conversion of disulfides to their reduced counterparts with the use of tris(2-carboxyethyl)phosphine. After reduction the newly formed sulfhydryl
    Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione
    Dringen R, et al.
    The Journal of Neuroscience, 19(2), 562-569 (1999)
    Purification and characterization of a Cys-Gly hydrolase from the gastropod mollusk, Patella caerulea
    Cappiello M, et al.
    Journal of Enzyme Inhibition and Medicinal Chemistry, 31(6), 1560-1565 (2016)
    Rita Ferin et al.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 911, 15-20 (2012-12-12)
    Alterations in the plasma aminothiols levels can be considered as important biomarkers for the diagnosis and screening of several human disorders, namely cardiovascular diseases. We aimed to optimize a rapid, sensitive and accurate RP-HPLC methodology with fluorescence detection, for the
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