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C0621

Sigma-Aldrich

CI−994

≥98% (HPLC), powder

Synonym(s):

4-Acetylamino-N-(2′-aminophenyl)benzamide, Acetyldinaline, Tacedinaline

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About This Item

Empirical Formula (Hill Notation):
C15H15N3O2
CAS Number:
112522-64-2
Molecular Weight:
269.30
MDL number:
MFCD00866266
UNSPSC Code:
12352200
PubChem Substance ID:
329774808
NACRES:
NA.77
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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

off-white

solubility

DMSO: >10 mg/mL

storage temp.

room temp

SMILES string

CC(=O)Nc1ccc(cc1)C(=O)Nc2ccccc2N

InChI

1S/C15H15N3O2/c1-10(19)17-12-8-6-11(7-9-12)15(20)18-14-5-3-2-4-13(14)16/h2-9H,16H2,1H3,(H,17,19)(H,18,20)

InChI key

VAZAPHZUAVEOMC-UHFFFAOYSA-N

Gene Information

human ... HDAC1(3065), HDAC10(83933), HDAC11(79885), HDAC2(3066), HDAC3(8841), HDAC4(9759), HDAC5(10014), HDAC6(10013), HDAC7(51564), HDAC8(55869), HDAC9(9734)

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1 of 4

This Item
340502190845363146
Poly(vinyl alcohol-co-ethylene) ethylene 32 mol %

414093

Poly(vinyl alcohol-co-ethylene)

Poly(ethylene-co-vinyl acetate) vinyl acetate 40 wt. %, melt index (41-63 dg/min (190°C/2.16kg)), contains 190-910 ppm inhibitor

340502

Poly(ethylene-co-vinyl acetate)

Poly(1-vinylpyrrolidone-co-vinyl acetate) average Mw ~50,000 (GPC vs. poly(ethylene oxide)), powder

190845

Poly(1-vinylpyrrolidone-co-vinyl acetate)

Poly(vinyl alcohol) Mw 85,000-124,000, 99+% hydrolyzed

363146

Poly(vinyl alcohol)

form

pellets

form

beads

form

powder

form

powder or crystals

density

1.19 g/mL at 25 °C

density

-

density

1.27 g/mL at 25 °C (lit.)

density

-

melt index

3.8 g/10 min (210°C)

melt index

(41-63 dg/min (190°C/2.16kg))

melt index

-

melt index

-

composition

ethylene, 32 mol %

composition

vinyl acetate, 40 wt. %

composition

-

composition

-

hardness

100 (Rockwell M, ASTM D 785)

hardness

40 (Shore A-2, ASTM D 2240)

hardness

-

hardness

-

impurities

<0.7% polymerized vinyl acetate

impurities

-

impurities

-

impurities

-

Application

CI-994 has been used:
  • as an histone deacetylase (HDAC) inhibitor to treat SUM229 and DT22 cells to study its effects[1]
  • as an HDAC inhibitor for screening in SPEL cells[2]
  • to study its effects on human myeloid and erythroid progenitors[3]

Biochem/physiol Actions

CI-994 is the acetylated derivative form of the original compound Dinaline (PD 104 208). It is an oral cytostatic drug with impressive differential activity against leukemic cells & normal stem-cells. It is used for combination therapy for selected tumors including non-small cell lung, pancreatic, breast, and colorectal cancers. It acts as a histone deacetylase inhibitor. CI-994 blocks cells in the G1-S phase of the cell cycle. The 16 kDa phosphoprotein is confined to the nuclear compartment. Loss of the 16-kDa nuclear phosphoprotein appears to be a direct effect of CI-994 treatment and that the inhibition of this phosphoprotein may play a critical role in the mechanism of action of CI-994.
Orally available HDAC Inhibitor; CI-994 blocks cells in the G1-S phase of the cell cycle.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
045M4737V
044M4770V
059K47211V
059K4721

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High performance filtration nanofibrous membranes based on hydrophilic poly (vinyl alcohol-co-ethylene) copolymer
Li M, et al.
Desalination, 329, 50-56 (2013)
K Khanah Mokwena et al.
Critical reviews in food science and nutrition, 52(7), 640-650 (2012-04-26)
Ethylene vinyl alcohol (EVOH) is one of the best known flexible thermoplastic oxygen barrier materials in use today. It is especially important for refrigerated and shelf-stable foods where oxygen deteriorates the quality of packaged products and reduces their shelf life.
Antonio Martínez-Abad et al.
Journal of agricultural and food chemistry, 60(21), 5350-5359 (2012-05-15)
The use of silver as an antimicrobial in the food area has raised wide interest in recent years. In the present work, 0.001-10 wt % silver ions was satisfactorily incorporated into an ethylene-vinyl alcohol (EVOH) copolymer matrix by a solvent
Brian C Gartrell et al.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 33(7), 1270-1275 (2012-07-18)
To report 3 unique cases of cranial neuropathy after super-selective arterial embolization of jugular foramen vascular tumors with ethylene vinyl alcohol. Clinical capsule report. Three tertiary academic referral hospitals. Three patients who underwent superselective arterial embolization (SSE) of head and
I-Chegn Chung et al.
Journal of nanoscience and nanotechnology, 11(12), 10633-10638 (2012-03-14)
The U.S. Food and Drug Administration allows a maximum of 72 mg of caffeine per 12 oz. serving (6 mg/oz). Consuming 400 mg of caffeine 3 times daily for 7 days may develop sleep disruption effects. However, it is still
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