C221

Carboxy-PTIO potassium salt

• Synonym(s): 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt, 2-(4-Carboxyphenyl)-4,5-dihydro-4,4,5,5-tetramethyl-1H-imidazol-1-yloxy-3-oxide potassium salt
• Empirical Formula (Hill Notation): C₁₄H₁₆KN₂O₄
• CAS Number: 148819-94-7
• Molecular Weight: 315.39
• MDL number: MFCD00216153
• UNSPSC Code: 12352200
• PubChem Substance ID: 24892474
• NACRES: NA.32

Properties

• biological source: synthetic (organic)
• Quality Level: 100
• assay: ≥98% (TLC)
• form: powder
• mp: >270 °C
• solubility: H₂O: 100 mg/mL; DMSO: soluble (lit.)(lit.); methanol: soluble (lit.)(lit.)
• storage temp.: 2-8°C
• SMILES string: [K+].CC1(C)N([O])C(c2ccc(cc2)C([O-])=O)=[N+]([O-])C1(C)C
• InChI: 1S/C14H17N2O4.K/c1-13(2)14(3,4)16(20)11(15(13)19)9-5-7-10(8-6-9)12(17)18;/h5-8H,1-4H3,(H,17,18);/q;+1/p-1
• InChI key: VYEUQMVIGXFZQU-UHFFFAOYSA-M

Description

General description

2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO) is mainly considered as a scavenger of nitric oxide (NO).[1]

Application

Carboxy-PTIO potassium salt has been used to check the generation of hydroxyl radicals or nitric in reaction mixtures to examine the generation of nitric oxide in reaction mixture.[2] It has also been added to neurons to analyse its effect on glucose/oxygen/serum deprivation (GOSD) condition(4)

Biochem/physiol Actions

Carboxy-PTIO can make a quick reaction with nitric oxide (NO) to produce nitrogen dioxide (NO₂).[3] It can be used to prevent hypotension and endotoxic shock, stimulated by lipopolysaccharide in- vivo. Carboxy-PTIO can also block in vitro vascular relaxation, stimulated by NO.[1]

Reacts with nitric oxide to form carboxy-PTI derivatives which in turn inhibits nitric oxide synthase.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)