C6240

CITCO

≥98% (HPLC), solid

• Synonym(s): 6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime
• Empirical Formula (Hill Notation): C₁₉H₁₂N₃OCl₃S
• CAS Number: 338404-52-7
• Molecular Weight: 436.74
• MDL number: MFCD00139608
• UNSPSC Code: 12352203
• PubChem Substance ID: 24724448
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• solubility: DMSO: soluble 28 mg/mL; H₂O: insoluble
• storage temp.: −20°C
• SMILES string: Clc1ccc(cc1)-c2nc3sccn3c2\C=N\OCc4ccc(Cl)c(Cl)c4
• InChI: 1S/C19H12Cl3N3OS/c20-14-4-2-13(3-5-14)18-17(25-7-8-27-19(25)24-18)10-23-26-11-12-1-6-15(21)16(22)9-12/h1-10H,11H2/b23-10+
• InChI key: ZQWBOKJVVYNKTL-AUEPDCJTSA-N

Description

General description

CITCO is an imidazothiazole derivative. It stimulates human constitutive androstane receptor (CAR) nuclear translocation.

Application

CITCO has been used for the activation of mouse constitutive androstane receptor (CAR) and human CAR.

Biochem/physiol Actions

CITCO is a constitutive androstane receptor (CAR) agonist; nuclear receptor NR113 agonist.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves