C7971

Cilostamide

phosphodiesterase inhibitor

• Synonym(s): 6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one, OPC 3689
• Empirical Formula (Hill Notation): C₂₀H₂₆N₂O₃
• CAS Number: 68550-75-4
• Molecular Weight: 342.43
• MDL number: MFCD00673958
• UNSPSC Code: 12352202
• PubChem Substance ID: 24278337
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: powder
• solubility: DMSO: 20 mg/mL, clear, colorless to faintly yellow
• SMILES string: CN(C1CCCCC1)C(=O)CCCOc2ccc3NC(=O)C=Cc3c2
• InChI: 1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
• InChI key: UIAYVIIHMORPSJ-UHFFFAOYSA-N
• Gene Information: human ... PDE3A(5139), PDE3B(5140), PDE5A(8654), PDE7A(5150) ; rat ... Pde2a(81743), Pde4a(25638)

Description

Biochem/physiol Actions

PDE3 catalyzes the phosphodiester bond hydrolysis, observed in secondory messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Inhibitors of PDE3 are generally inotropic and vasodilatory. They are being recognized for its use in treating heart failures. Cilostamide is known to delay meiotic progression.

Selective cGMP-inhibited phosphodiesterase inhibitor (PDE3); IC₅₀ = 70 ± 9 nM.

Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC₅₀ = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)