D1411

d-Desthiobiotin

≥98% (TLC)

• Synonym(s): 5-Methyl-2-oxo-4-imidazolidinehexanoic acid
• Empirical Formula (Hill Notation): C₁₀H₁₈N₂O₃
• CAS Number: 533-48-2
• Molecular Weight: 214.26
• EC Number: 208-566-2
• MDL number: MFCD00213804
• UNSPSC Code: 12352200
• eCl@ss: 34058011
• PubChem Substance ID: 24893431
• NACRES: NA.25

Properties

• Quality Level: 200
• assay: ≥98% (TLC)
• form: powder
• storage temp.: 2-8°C
• SMILES string: C[C@@H]1NC(=O)N[C@@H]1CCCCCC(O)=O
• InChI: 1S/C10H18N2O3/c1-7-8(12-10(15)11-7)5-3-2-4-6-9(13)14/h7-8H,2-6H2,1H3,(H,13,14)(H2,11,12,15)/t7-,8+/m0/s1
• InChI key: AUTOLBMXDDTRRT-JGVFFNPUSA-N

Description

Application

d-Desthiobiotin has been used as a component of elution buffers:

• to elute the precipitated proteins from the resin during coimmunoprecipitation
• to elute human Cdc45–MCM–GINS (CMG) helicase during chromatographic protein purification
• to elute the heterodimeric kinesin family member 3A/B (KIF3A/B) and kinesin associated protein 3 (KAP3)-binding APC armadillo (APCARM) domain during chromatographic purification

d-Desthiobiotin is used in affinity chromatography and protein chromatography. d-Desthiobiotin can be used for protein labeling, detection and isolation.

Biochem/physiol Actions

Desthiobiotin is a non-sulfur containing biotin derivative that binds less strongly to biotin-binding proteins and is easily dislocated by biotin.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)