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D1507

Sigma-Aldrich

L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride

≥98% (HPLC), solid,  L-DOPA precursor

Synonym(s):

Methyl L-DOPA hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C10H13NO4 · HCl
CAS Number:
1421-65-4
Molecular Weight:
247.68
MDL number:
MFCD00038958
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24278358
NACRES:
NA.77
Pricing and availability is not currently available.

Product Name

L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride, solid

form

solid

Quality Level

200

color

white to off-white

storage temp.

−20°C

SMILES string

Cl[H].COC(=O)[C@@H](N)Cc1ccc(O)c(O)c1

InChI

1S/C10H13NO4.ClH/c1-15-10(14)7(11)4-6-2-3-8(12)9(13)5-6;/h2-3,5,7,12-13H,4,11H2,1H3;1H/t7-;/m0./s1

InChI key

WFGNJLMSYIJWII-FJXQXJEOSA-N

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1 of 4

This Item
UC168SML0091N5751
L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride solid

D1507

L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride

(±)-Bufuralol hydrochloride

UC168

(±)-Bufuralol hydrochloride

L-Dopa ethyl ester ≥98% (HPLC)

SML0091

L-Dopa ethyl ester

Nω-Nitro-L-arginine methyl ester hydrochloride ≥97% (TLC), powder

N5751

Nω-Nitro-L-arginine methyl ester hydrochloride

form

solid

form

solid

form

powder

form

powder

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

200

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

color

white to off-white

color

white to off-white

color

white to tan

color

white to off-white

Application

L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride has been used:
  • in treating 6-hydroxydopamine induced lesions mice serotonin neurons[1]
  • in tyrosinase activity in B16F10 skin melanoma cells[2]
  • to test its neuroprotective effect in mesencephalic neurons[3]

Biochem/physiol Actions

L-3,4-Dihydroxyphenylalanine methyl ester is a precursor to L-DOPA[4] that crosses the blood-brain barrier.[5] Antiparkinsonian agent L-DOPA methyl ester elicits antitumor functionality in leukemia and melanoma.[6]

Caution

Light sensitive

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SLCF5495
SLCF4517
SLCF4520
SLCD7024
SLBS9461

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Vesa Riihimäki et al.
Critical reviews in toxicology, 42(10), 827-853 (2012-09-28)
Exposure to aluminum at work is widespread, and people are exposed to several species of aluminum, which differ markedly as to the kinetics and toxicity. Especially welding of aluminum is widely applied and continuously expanding. Inhalation of fine particles of
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Cell biology and toxicology, 29(2), 75-84 (2013-03-07)
Metal pollutants are a global health risk due to their ability to contribute to a variety of diseases. Aluminum (Al), a ubiquitous environmental contaminant is implicated in anemia, osteomalacia, hepatic disorder, and neurological disorder. In this review, we outline how
Rejane C Marques et al.
Environmental pollution (Barking, Essex : 1987), 187, 130-135 (2014-02-04)
We studied neurodevelopment in infants from two communities. Children living in the vicinity of tin-ore kilns and smelters - TOKS; n = 51) were compared to children from a fishing village (Itapuã; n = 45). Mean hair-Hg (HHg) concentrations were significantly higher in Itapuã
Y Z Zhu et al.
Environmental toxicology and pharmacology, 35(1), 82-87 (2013-01-01)
Aluminum (Al) is widely used in daily life and will lead to environmental release and exposure. The toxicity of Al had been documented, and which attracted a growing concern on human and animal health. The immune system appears to be
Jian-Yong Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(17), 6503-6508 (2014-04-15)
Aluminum (Al) toxicity is a major constraint for crop production on acid soils which compose ∼ 40% of arable land in the tropics and subtropics. Rice is the most Al-tolerant cereal crop and offers a good model for identifying Al
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