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D4071

Sigma-Aldrich

5, 15-DPP

Synonym(s):

5,15-Diphenyl-21H,23H-porphine, 5,15-Diphenylporphyrin, 5,15-diphenyl-Porphine

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10 MG
CA$107.00
50 MG
CA$314.00

About This Item

Empirical Formula (Hill Notation):
C32H22N4
CAS Number:
22112-89-6
Molecular Weight:
462.54
MDL number:
MFCD08276335
UNSPSC Code:
12352200
PubChem Substance ID:
329798793
NACRES:
NA.77

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form

powder

Quality Level

100

SMILES string

c1ccc(cc1)-c2c3ccc(cc4ccc([nH]4)c(-c5ccccc5)c6ccc(cc7ccc2[nH]7)n6)n3

InChI

1S/C32H22N4/c1-3-7-21(8-4-1)31-27-15-11-23(33-27)19-25-13-17-29(35-25)32(22-9-5-2-6-10-22)30-18-14-26(36-30)20-24-12-16-28(31)34-24/h1-20,33,36H/b23-19-,24-20-,25-19-,26-20-,31-27-,31-28-,32-29-,32-30-

InChI key

FNNOEKVUXXVPAI-DUVOQLPESA-N

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This Item
D4007D4505SML0117
5, 15-DPP

D4071

5, 15-DPP

5,5-Diphenylhydantoin ≥98%

D4007

5,5-Diphenylhydantoin

5,5-Diphenylhydantoin sodium salt ≥99%

D4505

5,5-Diphenylhydantoin sodium salt

Fosphenytoin disodium salt hydrate ≥98% (HPLC)

SML0117

Fosphenytoin disodium salt hydrate

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

Application

5, 15-DPP has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:
  • to analyze its effects on malignant peripheral nerve sheath tumor (MPNST) survival and proliferation[1]
  • to study its effects on the thymic stromal lymphopoietin (TSLP) modulation of nometastatic gene 23-H1 (NME1 or nm23-H1) expression in human trophoblasts[2]
  • to study its effects on 17β-estradiol and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced M2 polarization in human macrophages and endometrial stromal cells[3]

Biochem/physiol Actions

5, 15-DPP is a selective STAT3 inhibitor and a selective STAT3-SH2 antagonist

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    036M4728V
    024M4724V
    041M4723V
    030M47371
    030M4737

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    Yun Wang et al.
    PloS one, 10(5), e0125559-e0125559 (2015-05-08)
    The goal of this study is to elucidate the effects of 17β-estradiol and TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) on macrophage phenotypes in the endometriotic milieu. Co-culture of endometrial stromal cells (ESCs) and U937 cells (macrophage cell line) was performed to simulate the endometriotic
    Ying Wang et al.
    Clinical immunology (Orlando, Fla.), 143(1), 88-95 (2012-03-01)
    Our previous study has demonstrated that TSLP induces the invasion of human trophoblasts and plays a role in embryo implantation. The present study is undertaken to explore the mechanism by which TSLP modulates trophoblast invasion. It was revealed that TSLP
    Jody Fromm Longo et al.
    Cell communication and signaling : CCS, 17(1), 74-74 (2019-07-12)
    We have found that erbB receptor tyrosine kinases drive Ras hyperactivation and growth in NF1-null malignant peripheral nerve sheath tumors (MPNSTs). However, MPNSTs variably express multiple erbB receptors with distinct functional characteristics and it is not clear which of these

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