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D6196

Sigma-Aldrich

Dimebon dihydrochloride hydrate

≥98% (HPLC)

Synonym(s):

2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride hydrate, Dimebolin dihydrochloride hydrate, Dimeboline dihydrochloride hydrate, Dimebone dihydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):
C21H25N3 · 2HCl · xH2O
CAS Number:
97657-92-6
Molecular Weight:
392.37 (anhydrous basis)
MDL number:
MFCD17215933
UNSPSC Code:
12352200
PubChem Substance ID:
329798824
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

H2O: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

O.Cl.Cl.CN1CCc2c(C1)c3cc(C)ccc3n2CCc4ccc(C)nc4

InChI

1S/C21H25N3.2ClH.H2O/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17;;;/h4-7,12-13H,8-11,14H2,1-3H3;2*1H;1H2

InChI key

QQHQMWVYYVVAOV-UHFFFAOYSA-N

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1 of 4

This Item
EMU022951EMU026871EMU060271
MISSION® esiRNA targeting mouse Ldlr

EMU015661

MISSION® esiRNA

MISSION® esiRNA targeting mouse Ldhc

EMU022951

MISSION® esiRNA

MISSION® esiRNA targeting mouse Ldb1

EMU026871

MISSION® esiRNA

MISSION® esiRNA targeting mouse Lgtn

EMU060271

MISSION® esiRNA

esiRNA cDNA target sequence

GACACCAAGGGCGTAAAGAGGAGGACACTGTTCCAAGAGGCAGGGTCCAGACCCAGAGCCATCGTAGTGGACCCTGTGCATGGCTTCATGTACTGGACAGATTGGGGAACACCCGCCAAGATCAAGAAAGGGGGTTTGAATGGTGTGGACATCCACTCACTGGTGACCGAAAACATCCAGTGGCCAAATGGCATCACACTAGATCTTTCCAGTGGCCGTCTCTATTGGGTTGATTCCAAACTCCACTCTATCTCCAGCATCGATGTCAATGGGGGCAATCGGAAAACCATTTTGGAGGATGAGAACCGGCTGGCCCACCCCTTCTCCTTGGCCATCTATGAGGACAAAGTGTATTGGACAGATGTCATAAACGAAGCCATTTTCAGTGCCAATCGACTCACGGGTTCAGATGTGAATTTGGTGGCTGAAA

esiRNA cDNA target sequence

CAGTGTGCCCATATGGAGTGGTGTAAACGTTGCTGGCGTAACTCTGAAGTCACTGAACCCAGCAATAGGAACTGACTCAGATAAGGAACACTGGAAAAATGTTCACAAGCAGGTGGTGGAAGGCGGCTATGAGGTCCTTAACATGAAGGGCTATACCTCTTGGGCTATCGGGCTGTCTGTGACTGATCTGGCGCGATCCATCTTGAAGAATCTTAAGAGAGTGCATCCTGTTACCACGCTGGTTAAGGGCTTCCATGGGATAAAGGAAGAGGTCTTCCTCAGTATCCCTTGTGTCTTGGGACAAAGTGGTATCACAGACTTTGTGAAAGTCAACATGACCGCTGAGGAGGAGGGTCTCCTCAAGAAGAGTGCGGACACACTCTGGAATATGCAGAAGGATCTGCAGTTATAAACTCGCCACCTTCGACCGTGTGACAGATGCCTGATC

esiRNA cDNA target sequence

TGCTGACCATCACTTTCTGCTTGGAGGATGGACCAAAGAGATATACCATTGGCCGGACCCTGATACCACGCTACTTCCGAAGCATTTTTGAGGGGGGTGCCACAGAGCTGTACTACGTGCTCAAGCACCCCAAGGAGGCATTCCACAGCAACTTCGTGTCCCTCGACTGTGACCAGGGCAGCATGGTGACCCAGCACGGCAAACCCATGTTTACCCAGGTGTGTGTGGAAGGCCGGTTGTACCTGGAGTTCATGTTTGACGACATGATGCGGATAAAGACGTGGCACTTCAGCATCCGGCAACACAGAGAGCTCATCCCCAGAAGTATCCTGGCCATGCACGCCCAGGACCCCCAGATGCTGGATCAGCTGTCCAAAAACATTACCCGGTGTGGGCTGTCCAATTCCACTCTCAACTACCTCCGACTCTGTGTGATACTAGAGCCCATGCAGGAACTT

esiRNA cDNA target sequence

GCAGCCTGCCTACCAAGTAACATTTCCTGGCCAGGAACCCATTCTAAAGAAAGGGAAACTCTGTCCAATTGATATCACCCTTGCACTGAAGACCTATAATAAAAAGGTGACTGTGGTCCGGAACTTGGAGACCTATGGTCTAGATCCGTGCTCAGTGGCCGCCATTCTCCAGCAGCGATGTCAGGCAAGCACCATCGTCTCTCCTGCCCCTGGGGCCAAAGACAGTCTGCAGGTGCAGGTCCAGGGAAACCAGATCCACCACCTTGGCCAGCTACTGCTTGAAATCATGTGGTGAGCCCCGGCAGTGCCTGGAGCTCAGCGGTGCTGTGACAGGGATCCCCTTGCTTATAACTGTGCTGCAGGACTGTTGCCTGTATTGCAGATGGGAAAACTGAGGTCCA

Gene Information

mouse ... LDLR(16835), Ldlr(16835)

Gene Information

mouse ... LDHC(16833), Ldhc(16833)

Gene Information

mouse ... LDB1(16825), Ldb1(16825)

Gene Information

mouse ... LGTN(16865), Lgtn(16865)

Ensembl | mouse accession no.

ENSMUSG00000032193

Ensembl | mouse accession no.

ENSMUSG00000030851

Ensembl | mouse accession no.

ENSMUSG00000025223

Ensembl | mouse accession no.

ENSMUSG00000026427

product line

MISSION®

product line

MISSION®

product line

MISSION®

product line

MISSION®

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

NCBI accession no.

NM_010700

NCBI accession no.

NM_013580

NCBI accession no.

NM_010697

NCBI accession no.

NM_010709

Biochem/physiol Actions

Mechanism of neuroprotection and cognition enhancement is not certain, but Dimebon blocks both cholinesterase and the NMDA receptor simultaneously and also appears to block the action of neurotoxic β-amyloid proteins and inhibit L-type calcium channels, and may exert a neuroprotective effect by blocking a novel target that involves mitochondrial pores.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    050M4626V
    050M4626

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    Nobuhiko Kayagaki et al.
    Science (New York, N.Y.), 341(6151), 1246-1249 (2013-07-28)
    Gram-negative bacteria including Escherichia coli, Citrobacter rodentium, Salmonella typhimurium, and Shigella flexneri are sensed in an ill-defined manner by an intracellular inflammasome complex that activates caspase-11. We show that macrophages loaded with synthetic lipid A, E. coli lipopolysaccharide (LPS), or
    The enterotoxin T (BcET) from Bacillus cereus can probably not contribute to food poisoning.
    Choma C and Granum PE
    FEMS Microbiology Letters, 217, 115-115 (2002)
    Nicholas F Wright et al.
    The Journal of comparative neurology, 521(13), 2966-2986 (2013-03-19)
    Many brain structures project to both the anteroventral thalamic nucleus and the anteromedial thalamic nucleus. In the present study, pairs of different tracers were placed into these two thalamic sites in the same rats to determine the extent to which
    Contribution of CXCL12 secretion to invasion of breast cancer cells.
    Boimel PJ et al.
    Breast Cancer Research, 14, R23-R23 (2012)
    Rapid Expansion of Human Epithelial Stem Cells Suitable for Airway Tissue Engineering.
    Butler CR et al.
    American Journal of Respiratory and Critical Care Medicine, 194, 156-156 (2016)
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