D7693

Dynasore hydrate

≥97.5% (HPLC), powder, dynamin 1 and dynamin 2 GTPase activity inhibitor

• Synonym(s): 3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide hydrate
• Empirical Formula (Hill Notation): C₁₈H₁₄N₂O₄ · xH₂O
• CAS Number: 1202867-00-2
• Molecular Weight: 322.31 (anhydrous basis)
• MDL number: MFCD11045288
• UNSPSC Code: 12352200
• PubChem Substance ID: 329798784
• NACRES: NA.77

Properties

• Product Name: Dynasore hydrate,
• form: powder
• Quality Level: 100
• storage condition: protect from light
• color: off-white
• solubility: DMSO: ≥10 mg/mL; H₂O: insoluble
• storage temp.: −20°C
• SMILES string: O.Oc1ccc(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O
• InChI: 1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;
• InChI key: FKWZHQSDBMSHTN-ZIOFAICLSA-N

Description

General description

Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.

Application

Dynasore hydrate has been used:

• for priming fetal mesenchymal stem/stromal cells (fMSC)
• in confocal microscopy
• in wound healing/scratch and tube-formation assay
• to analyse its effects on Coxsackievirus A9 (CAV9) infection
• to inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosis
• in live imaging of cells

Biochem/physiol Actions

Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• pictograms: GHS09
• signalword: Warning
• hcodes: H400
• pcodes: P273
• Hazard Classifications: Aquatic Acute 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves