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E6530

Sigma-Aldrich

Etomidate

>98% (HPLC), powder

Synonym(s):

(R)-1-(α-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester, Amidate, R16659

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About This Item

Empirical Formula (Hill Notation):
C14H16N2O2
CAS Number:
33125-97-2
Molecular Weight:
244.29
EC Number:
251-385-9
MDL number:
MFCD00869295
UNSPSC Code:
12352200
PubChem Substance ID:
24894630
NACRES:
NA.77
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Quality Level

100

assay

>98% (HPLC)

form

powder

color

white

solubility

DMSO: >10 mg/mL

originator

Johnson & Johnson

storage temp.

2-8°C

SMILES string

CCOC(=O)c1cncn1[C@H](C)c2ccccc2

InChI

1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1

InChI key

NPUKDXXFDDZOKR-LLVKDONJSA-N

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General description

Etomidate is an imidazole derivative, which functions as an nonbarbiturate hypnotic agent. It is used in speech and memory test.[1] Etomidate regulates hemodynamic stability by preserving sympathetic outflow and autonomic reflexes.[2] It inhibits adrenal steroidogenesis.[3]

Biochem/physiol Actions

Etomidate is a general anesthetic; potentiates GABAA transmission
Etomidate is a general anesthetic; potentiates GABAA transmission. The possible neuroprotective effect of etomidate against streptozotocin-induced (STZ-induced) hyperglycaemia were investigated in the rat brain and spinal cord. Etomidate treatment demonstrated neuroprotective effect on the neuronal tissue against the diabetic oxidative damage

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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    Certificates of Analysis (COA)

    Lot/Batch Number
    063M4726V
    070M4706
    089K47091
    089K4709
    057K47134

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