E8515

β-Estradiol 3-benzoate

≥97%

• Synonym(s): 1,3,5(10)-Estratriene-3,17β-diol 3-benzoate, 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-benzoate, 3-Benzoyloxy-17β-estrol
• Empirical Formula (Hill Notation): C₂₅H₂₈O₃
• CAS Number: 50-50-0
• Molecular Weight: 376.49
• Beilstein/REAXYS Number: 3107526
• EC Number: 200-043-7
• MDL number: MFCD00003692
• UNSPSC Code: 51111800
• PubChem Substance ID: 24894677
• NACRES: NA.77
• assay: ≥97%

Properties

• Quality Level: 200
• assay: ≥97%
• mp: 191-198 °C (lit.)
• SMILES string: [H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(OC(=O)c5ccccc5)ccc24
• InChI: 1S/C25H28O3/c1-25-14-13-20-19-10-8-18(28-24(27)16-5-3-2-4-6-16)15-17(19)7-9-21(20)22(25)11-12-23(25)26/h2-6,8,10,15,20-23,26H,7,9,11-14H2,1H3/t20-,21-,22+,23+,25+/m1/s1
• InChI key: UYIFTLBWAOGQBI-BZDYCCQFSA-N

Description

Application

β-Estradiol 3-benzoate has been used:to mimic estradiol in rat during the oestrous cycle in rats. It has also been used along with progesterone for the induction of sexual receptivity in female rat.

Used in a study of general steroid metabolism and clearing, as groundwork for anabolic steroid screening in athletes.

Biochem/physiol Actions

β-Estradiol 3-benzoate is a synthetic estrogen. It favors breast cancer progression. It is an endocrine disrupting chemicals. It interacts with endocrine system and cause harmful effect on reproduction in animals and humans. It binds to estrogen receptors and favors tumor metastatis in breast, prostate and bone cells.

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H351,H360FD
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Carc. 2 - Repr. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges