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EHU160391

MISSION^® esiRNA

Name: MISSION<SUP>®</SUP> esiRNA
Brand: SIGMA

targeting human GALNT1

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About This Item

UNSPSC Code:

41105324

NACRES:

NA.51

Pricing and availability is not currently available.

description

Quality Level

100

product line

MISSION^®

form

lyophilized powder

esiRNA cDNA target sequence

CTTGCAGAAGTGTGGATGGATGAATTCAAGAATTTCTTCTATATAATTTCTCCAGGTGTTACAAAGGTAGATTATGGAGATATATCGTCAAGAGTTGGTCTAAGACACAAACTACAATGCAAACCTTTTTCCTGGTACCTAGAGAATATATATCCTGATTCTCAAATTCCACGTCACTATTTCTCATTGGGAGAGATACGAAATGTGGAAACGAATCAGTGTCTAGATAACATGGCTAGAAAAGAGAATGAAAAAGTTGGAATTTTTAATTGCCATGGTATGGGGGGTAATCAGGTTTTCTCTTATACTGCCAACAAAGAAATTAGAACAGATGACCTTTGCTTGGATGTTTCCAAACTTAATGGCCCAGTTACAATGCTCAAATGCCACCACCTAAAAGGCAACCAACTCTGGGAGTATGACCCAGTGAAATTAACCCTGCAGCATGTGAAC

Ensembl | human accession no.

ENSG00000141429

NCBI accession no.

NM_020474

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... GALNT1(2589), GALNT1(2589)

Related Categories

MISSION® esiRNA

Oligos, qPCR Probes & Peptides

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This Item	49549	1327319	PHL80863
PHL80474 4-Hydroxy-L-isoleucine	49549 4-Hydroxy-L-isoleucine	1327319 4-Hydroxyisoleucine	PHL80863 4-Hydroxyisophthalic acid
grade primary reference standard	grade -	grade pharmaceutical primary standard	grade primary reference standard
product line phyproof^® Reference Substance	product line -	product line -	product line phyproof^® Reference Substance
assay ≥98.0% (HPLC)	assay ≥98.0% (TLC)	assay -	assay ≥90.0% (HPLC)
form solid	form -	form -	form solid
manufacturer/tradename PhytoLab	manufacturer/tradename -	manufacturer/tradename USP	manufacturer/tradename PhytoLab

General description

MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Knockdown of GALNT1 suppresses malignant phenotype of hepatocellular carcinoma by suppressing EGFR signaling.

Miao-Juei Huang et al.

Oncotarget, 6(8), 5650-5665 (2015-03-03)

O-glycosylation is a common protein modification. Aberrant O-glycosylation is associated with many cancers. GALNT1 is a GalNAc-transferase that initiates protein O-glycosylation. We found that GALNT1 is frequently up-regulated in hepatocellular carcinoma (HCC) and is associated with poor patient survival. Overexpression

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