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G5172

Sigma-Aldrich

GW4064

≥97% (HPLC)

Synonym(s):

3-(2,6-Dichlorophenyl)-4-(3’-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole

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About This Item

Empirical Formula (Hill Notation):
C28H22Cl3NO4
CAS Number:
Molecular Weight:
542.84
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32
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Quality Level

assay

≥97% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC(C)c1onc(c1COc2ccc(\C=C\c3cccc(c3)C(O)=O)c(Cl)c2)-c4c(Cl)cccc4Cl

InChI

1S/C28H22Cl3NO4/c1-16(2)27-21(26(32-36-27)25-22(29)7-4-8-23(25)30)15-35-20-12-11-18(24(31)14-20)10-9-17-5-3-6-19(13-17)28(33)34/h3-14,16H,15H2,1-2H3,(H,33,34)/b10-9+

InChI key

BYTNEISLBIENSA-MDZDMXLPSA-N

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D1692G6416A1987
GW4064 ≥97% (HPLC)

G5172

GW4064

GW4869 ≥90% (NMR)

D1692

GW4869

GW5074 powder

G6416

GW5074

AM6545 ≥98% (HPLC)

A1987

AM6545

form

powder

form

powder

form

powder

form

powder

assay

≥97% (HPLC)

assay

≥90% (NMR)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 0.2 mg/mL

solubility

DMSO: 5 mg/mL, clear

solubility

DMSO: >25 mg/mL

storage condition

desiccated

storage condition

desiccated, protect from light

storage condition

protect from light

storage condition

-

General description

GW4064 is a synthetic isoxazole, which is used to decipher the cellular and physiological functions of farnesoid X receptor (FXR). It is an estrogen receptor-related receptors (ERRs) agonist.[1]

Application

GW4064 has been used:
  • to investigate its ability to protect the livers of mice from lipopolysaccharide (LPS)-induced inflammation and apoptosis[2]
  • to examine its capability to inhibit mucosal injury in ileum caused by lipopolysaccharide (LPS)[3]
  • to treat ileal explants[4]

Biochem/physiol Actions

GW4064 is a FXR agonist. GW4064 is a potent (EC50 = 15 nM), non-steroidal agonist of the orphan nuclear receptor FXR. It shows no activity on other nuclear receptors including RAR up to 1 mM. This is an important tool for the study of the involvment of FXR in a variety of biological activities.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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