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GW22308F

Sigma-Aldrich

Anti-GIPC1 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, human, mouse

manufacturer/tradename

Genway 15-288-22308F

technique(s)

western blot: suitable

NCBI accession no.

NP_005707.1

UniProt accession no.

O14908

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GIPC1(10755)

Immunogen

Immunogen Sequence: GI # 5031715, sequence 1-333
Recombinant regulator of G-protein signalling 19 interacting protein 1 isoform 1

Application

Anti-GIPC1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

GIPC PDZ domain containing family, member 1 (GIPC1) is a protein encoded by the GIPC1 gene in humans. The mammalian GIPC1 consists of a central PDZ domain and a C-terminal acyl carrier protein (ACP) domain. It is an essential adaptor protein of receptors that plays an important role in cancer progression and therapy resistance. The GIPC1 cytoplasmic scaffold protein interacts with numerous receptor signaling complexes and plays a role in tumorigenesis. It is highly expressed in a number of human malignancies that include breast, ovarian, gastric and pancreatic cancers. GIPC1 inhibition may be a new target for therapeutic development for the treatment of human cancers. It is a breast cancer-associated immunogenic antigen that is overexpressed in breast cancer.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
039K1890
029K2225

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L De Vries et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(21), 12340-12345 (1998-10-15)
We have identified a mammalian protein called GIPC (for GAIP interacting protein, C terminus), which has a central PDZ domain and a C-terminal acyl carrier protein (ACP) domain. The PDZ domain of GIPC specifically interacts with RGS-GAIP, a GTPase-activating protein
A Singer et al.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 188(12), 1125-1132 (2012-11-07)
Studies have shown that GIPC1/Synectin is an essential adaptor protein of receptors that play an important role in cancer progression and therapy resistance. This is the first study to explore the role of GIPC1/Synectin in radioresistance of prostate cancer and
Thomas W Chittenden et al.
PloS one, 5(12), e15581-e15581 (2011-01-07)
GIPC1 is a cytoplasmic scaffold protein that interacts with numerous receptor signaling complexes, and emerging evidence suggests that it plays a role in tumorigenesis. GIPC1 is highly expressed in a number of human malignancies, including breast, ovarian, gastric, and pancreatic
Sergei Rudchenko et al.
BMC cancer, 8, 248-248 (2008-08-30)
We have been studying the native autoimmune response to cancer through the isolation of human monoclonal antibodies that are cancer specific from cancer patients. To facilitate this work we previously developed a fusion partner cell line for human lymphocytes, MFP-2

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