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GW22348F

Sigma-Aldrich

Anti-LXN antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
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biological source

chicken

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse, rat

manufacturer/tradename

Genway 15-288-22348F

technique(s)

indirect ELISA: suitable
western blot: suitable

General description

LXN (latexin) is the human homologue of endogenous inhibitor of carboxypeptidase A found in rat. It was initially recognized as a neural marker in developing mammalian brain, of the lateral neocortex. This protein is composed of 222 amino acids. An α-helix links two subdomains that comprise the protein. It has high structural homology to TIG1 (tazarotene-induced gene 1).

Immunogen

Immunogen Sequence: GI # 9910396, sequence 1-222
Recombinant latexin protein

Application

Anti-LXN antibody produced in chicken is suitable for indirect ELISA and western blotting.

Biochem/physiol Actions

Latexin (LXN) is a negative regulator of hematopoietic stem cell and may exert its tumor-suppressive function by altering the stem cell-like properties of melanoma cells. Its expression is reduced in human gastric cancers compared with their normal control tissues. LXN expression may have involvement in tumor suppression. It may have clinical efficacy in the treatment of malignancies.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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