GW22692
Anti-CD55 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-CD55
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About This Item
biological source
chicken
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-22692
technique(s)
western blot: suitable
Immunogen
Immunogen Sequence: GI # 10835143, sequence 36-129
Recombinant decay accelerating factor for complement
Application
Anti-CD55 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Complement decay-accelerating factor (decay-accelerating factor, DAF) is a protein encoded by the CD55 gene in humans. It plays multiple functions including tissue protection from the cytotoxic complement injury and an anti-inflammatory function due to its anti-adherence properties. It is essential in many organ systems including pregnancy for protection of the semiallogeneic fetus or for preventing uncontrolled infiltration by white cells in their pro- and/or anti-inflammatory functions. Expression of CD55 appears to have multiple regulatory tissue-specific and/or menstrual cycle-specific mechanisms that are involved in complex signaling mechanisms. Its regulation may involve a direct or an indirect effect of at least the estrogen, progesterone, and corticosteroid regulatory pathways. It plays a a primary role in conferring resistance to lysis. CD55 is overexpressed in several types of cancer.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Yanxia Wu et al.
American journal of physiology. Gastrointestinal and liver physiology, 306(12), G1056-G1064 (2014-04-26)
Engineering cancer cells to express heterologous antigen α-gal and induce the destruction of tumor cells depending on the complement cascade may be a promising strategy of tumor therapy. However, the feasibility and effect of using α-gal to induce colorectal adenocarcinoma
E D Vainer et al.
Tissue antigens, 82(1), 26-34 (2013-05-23)
CD55 (decay-accelerating factor, DAF) is overexpressed in several types of cancer, including colorectal cancer. Because of its inhibitory effect on the complement system, it has been suggested as a possible target for cancer immunotherapy. However, CD55 is also expressed in
Bogdan Nowicki et al.
Advances in experimental medicine and biology, 735, 83-96 (2013-02-14)
In this chapter, we present a concise historic prospective and a summary of accumulated knowledge on steroid hormones, DAF expression, and therapeutic implication of steroid hormone treatment on multiple pathologies, including infection and the host-pathogen interactions. DAF/CD55 plays multiple physiologic
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