H2167

Histone H2B human

• Synonym(s): Histone, Human
• CAS Number: 1523001-32-2
• UNSPSC Code: 12352202
• NACRES: NA.25

Properties

• biological source: human
• Quality Level: 200
• recombinant: expressed in E. coli
• form: liquid
• concentration: 1 mg/mL
• UniProt accession no.: Q96A08
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... H2BC1(255626)

Description

General description

Histones are highly basic chromatin proteins. They tightly organize eukaryotic DNA into nucleosomes. A nucleosome exists as an octameric core histone comprising a tetramer of histones H3 and H4 with two dimers of histones H2A and H2B, wherein the 147 DNA base pairs are wrapped around the histone complex.

Application

Histone H2B human has been used in far western blot analysis.

Biochem/physiol Actions

Histones are known to regulate the accessibility of DNA during transcription, DNA replication, DNA repair, and recombination. Extrachromosomal histone H2B functions as a cytosolic sensor and detects the double-stranded DNA (dsDNA) fragments produced from infectious agents or damaged cells. This stimulates innate and acquired immune responses in different cell types. Histone H2B moves in and out of the nucleosome more quickly than other core histones.

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H350
• pcodes: P201 - P308 + P313
• Hazard Classifications: Carc. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable