Skip to Content
MilliporeSigma

Key Documents

View All Documentation

Skip To

H6649

Sigma-Aldrich

Herbimycin A from Streptomyces hygroscopicus

≥95% (HPLC), powder

Sign Into View Organizational & Contract Pricing

Select a Size

250 G
$443.00

$443.00

Please contact Customer Service for Availability
Request a Bulk Order

Select a Size

Change View
250 G
$443.00

About This Item

Empirical Formula (Hill Notation):
C30H42N2O9
CAS Number:
70563-58-5
Molecular Weight:
574.66
Beilstein/REAXYS Number:
4834067
MDL number:
MFCD00151702
UNSPSC Code:
12352200
PubChem Substance ID:
24895756
NACRES:
NA.77

$443.00

Please contact Customer Service for Availability
Request a Bulk Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

Streptomyces hygroscopicus

Quality Level

200

assay

≥95% (HPLC)

form

powder

color

yellow

solubility

DMSO: 7.5 mg/mL

antibiotic activity spectrum

viruses

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

CO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1OC)C2=O

Looking for similar products? Visit Product Comparison Guide

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
H9773H3274A3835
Herbimycin A from Streptomyces hygroscopicus ≥95% (HPLC), powder

H6649

Herbimycin A from Streptomyces hygroscopicus

Hygromycin B from Streptomyces hygroscopicus suitable for plant cell culture, BioReagent, ≥60% (HPLC), lyophilized powder

H9773

Hygromycin B from Streptomyces hygroscopicus

Hygromycin B from Streptomyces hygroscopicus powder, BioReagent, suitable for cell culture, suitable for insect cell culture

H3274

Hygromycin B from Streptomyces hygroscopicus

Ascomycin from Streptomyces hygroscopicus var. ascomyceticus

A3835

Ascomycin from Streptomyces hygroscopicus var. ascomyceticus

assay

≥95% (HPLC)

assay

-

assay

-

assay

-

form

powder

form

lyophilized powder

form

powder

form

powder

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 7.5 mg/mL

solubility

H2O: soluble 50 mg/mL, ethanol: soluble, methanol: soluble

solubility

H2O: 50 mg/mL (As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 30 days.)

solubility

-

color

yellow

color

faintly brown to brown, white to beige

color

faintly brown to brown, white to beige

color

-

General description

DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.
Herbimycin A from Streptomyces hygroscopicus is a benzoquinoid ansamycin antibiotic.[1] It is an analog of geldanamycin.[2]

Application

Herbimycin A from Streptomyces hygroscopicus has been used as an inhibitor of Src tyrosine kinase in HEK293T cells[3] and rat intestinal epithelial cells.[4] It has also been used to test its attenuation effect in intimal hyperplasia (IH) post balloon injury in rat carotid artery.[1]

Biochem/physiol Actions

An antibiotic that inhibits protein tyrosine kinase. Herbimycin A is a potent inhibitor of angiogenesis.
Herbimycin A is an inducer of heat shock protein (HSP). It increases HSP expression resulting in the attenuation of ischemia reperfusion induced pulmonary injury.[1]

Caution

Hygroscopic and photosensitive

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)

  • Specification Sheet

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    SLCL1131
    SLCK3695
    SLCF6017
    SLBS2836V
    SLBQ3791V

    Don't see the Right Version?

    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

    Search for a COA

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Ultrastretchable Conductor Fabricated on Skin-Like Hydrogel-Elastomer Hybrid Substrates for Skin Electronics
    Kim SH, et al.
    Advanced Materials, 30(26), 1800109-1800109 (2018)
    Fundamentals and Techniques of Biophysics and Molecular Biology (2018)
    Depletion of hemoglobin and carbonic anhydrase from erythrocyte cytosolic samples by preparative clear native electrophoresis
    Damici GM, et al.
    Nature Protocols, 7(1), 36-36 (2012)
    Ashok Kumar et al.
    Nature protocols, 5(11), 1737-1747 (2010-10-30)
    In cell affinity chromatography, type-specific cell separation is based on the interaction between cell-surface receptors and an immobilized ligand on a stationary matrix. This protocol describes the preparation of monolithic polyacrylamide and polydimethylacrylamide cryogel affinity matrices that can be used
    Ghazaleh Haghiashtiani et al.
    Science advances, 6(35), eabb4641-eabb4641 (2020-09-15)
    Minimally invasive surgeries have numerous advantages, yet complications may arise from limited knowledge about the anatomical site targeted for the delivery of therapy. Transcatheter aortic valve replacement (TAVR) is a minimally invasive procedure for treating aortic stenosis. Here, we demonstrate
    View All Related Papers

    Articles

    NMR Analysis of Glycans

    Nuclear magnetic resonance (NMR) spectroscopy measures the extent to which a glycan or other molecule distorts a magnetic field.

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service