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HPA001605

Sigma-Aldrich

Anti-KRT18 antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-CK-18, Anti-Cell proliferation-inducing gene 46 protein, Anti-Cytokeratin 18, Anti-ENSG00000177083 antibody produced in rabbit, Anti-K18, Anti-Keratin 18

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About This Item

UNSPSC Code:
12352203
Human Protein Atlas Number:
HPA001605
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

technique(s)

immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:50-1:200

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2713427150-U27172-U
Vials, screw top with solid green Thermoset cap with PTFE liner, preassembled, pkg of 100 volume 15 mL, clear glass vial, O.D. × H 21 mm × 70 mm, thread for 18-400

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Vials, screw top with solid green Thermoset cap with PTFE liner, preassembled, pkg of 100

Vials, screw top with solid green Thermoset cap with PTFE liner, preassembled, pkg of 100 volume 2 mL, clear glass vial (standard opening - 4.6 mm), O.D. × H × I.D. 12 mm × 32 mm × 4.6 mm, thread for 8-425

27134

Vials, screw top with solid green Thermoset cap with PTFE liner, preassembled, pkg of 100

Vials, screw top with solid green Thermoset cap with PTFE liner, preassembled, pkg of 100 volume 7 mL, clear glass vial, O.D. × H 17 mm × 60 mm, thread for 15-425

27150-U

Vials, screw top with solid green Thermoset cap with PTFE liner, preassembled, pkg of 100

Vials, screw top with solid green Thermoset cap with PTFE liner, preassembled, pkg of 100 volume 22 mL, clear glass vial, O.D. × H 23 mm × 85 mm, thread for 20-400

27172-U

Vials, screw top with solid green Thermoset cap with PTFE liner, preassembled, pkg of 100

feature

closure type green melamine solid-top cap, closure type screw top vial

feature

closure type green melamine solid-top cap, closure type screw top vial

feature

closure type green melamine solid-top cap, closure type screw top vial

feature

closure type green melamine solid-top cap, closure type screw top vial

volume

15 mL

volume

2 mL

volume

7 mL

volume

22 mL

fitting

thread for 18-400

fitting

thread for 8-425

fitting

thread for 15-425

fitting

thread for 20-400

material

F217/PTFE cap liner, clear glass vial, PTFE liner, green melamine resin cap (solid-top)

material

F217/PTFE cap liner, PTFE liner, clear glass vial (standard opening - 4.6 mm), green melamine resin cap (solid-top)

material

F217/PTFE cap liner, PTFE liner, clear glass vial, green melamine resin cap (solid-top)

material

F217/PTFE cap liner, PTFE liner, clear glass vial, green melamine resin cap (solid-top)

packaging

pkg of 100 ea

packaging

pkg of 100 ea

packaging

pkg of 100 ea

packaging

pkg of 100 ea

O.D. × H

21 mm × 70 mm

O.D. × H

-

O.D. × H

17 mm × 60 mm

O.D. × H

23 mm × 85 mm

Specificity

Note: The Ensemble Gene ID has changed from ENSG00000177083in the 46:36 release of the database to ENSG00000111057 in the 48:36 release of the database.

Immunogen

Keratin, type I cytoskeletal 18 recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST73443

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

  • Specification Sheet

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    R00133
    R000133

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    Reeteka Sud et al.
    Molecular therapy. Nucleic acids, 3, e180-e180 (2014-07-30)
    In Alzheimer's disease, progressive supranuclear palsy, and a number of other neurodegenerative diseases, the microtubule associated protein tau aggregates to form intracellular neurofibrillary tangles and glial tangles, abnormal structures that are part of disease pathogenesis. Disorders with aggregated tau are
    Analytical performance of reagent for assaying tau protein in human plasma and feasibility study screening neurodegenerative diseases
    Yang S, et al.
    Scientific reports, 7(1), 9304-9304 (2017)
    Tau protein in cerebrospinal fluid: a biochemical marker for axonal degeneration in Alzheimer disease?
    Blennow K, et al.
    Molecular and Chemical Neuropathology, 26(3), 231-245 (1995)
    Rebecca L Mueller et al.
    Frontiers in molecular neuroscience, 14, 647054-647054 (2021-04-06)
    Over four decades ago, in vitro experiments showed that tau protein interacts with and stabilizes microtubules in a phosphorylation-dependent manner. This observation fueled the widespread hypotheses that these properties extend to living neurons and that reduced stability of microtubules represents
    Nora Lemke et al.
    The Journal of biological chemistry, 295(52), 18508-18523 (2020-11-01)
    Synapse loss is associated with motor and cognitive decline in multiple neurodegenerative disorders, and the cellular redistribution of tau is related to synaptic impairment in tauopathies, such as Alzheimer's disease and frontotemporal dementia. Here, we examined the cellular distribution of
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