I1507
Insulin human
≥95% (HPLC), semisynthetic, powder, non-sterile
About This Item
Recommended Products
biological source
semisynthetic
Quality Level
sterility
non-sterile
assay
≥95% (HPLC)
form
powder
concentration
>75%
technique(s)
cell culture | mammalian: suitable
solubility
0.01 M HCl: 0.5 mg/mL, clear to slightly hazy, colorless
UniProt accession no.
shipped in
ambient
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This Item | H7789 | H0164 | SAB4501366 |
---|---|---|---|
conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
biological source rabbit | biological source rabbit | biological source rabbit | biological source rabbit |
antibody form affinity isolated antibody | antibody form affinity isolated antibody | antibody form IgG fraction of antiserum | antibody form affinity isolated antibody |
UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
form buffered aqueous solution | form buffered aqueous solution | form buffered aqueous solution | form buffered aqueous solution |
General description
Insulin binds to the receptors of target cells in the liver, skeletal muscle and fat, b cells, brain cells, and many other cells. The insulin gene is located on human chromosome 11p15.5.[1]
Application
- in artificial cerebrospinal fluid (aCSF) to study the effect of preoptic area administration of insulin on core body temperature (CBT) in mice[2]
- in contact-mode scanning probe electrospray ionization (SPESI) to study the effect of substrate vibration on ionization efficiency[3]
- as a component of adipocyte differentiation media[4][5][6]
Biochem/physiol Actions
Insulin signaling is associated with two important pathways namely: phosphatidylinositol 3-kinase (PI3K, a lipid kinase)/AKT (also known as PKB or protein kinase B) pathway and the Raf/Ras/MEK/ MAPK (mitogen-activated protein kinase, also known as ERK or extracellular signal-regulated kinase) pathway. Insulin increases the metabolic pathways controlling glycogen synthesis, gene expression, DNA synthesis, and Na+/K+ pump. It inhibits metabolic pathways regulating apoptosis and autophagy.
Other Notes
Preparation Note
antibody
related product
Storage Class
11 - Combustible Solids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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