I3036
Polyinosinic–polycytidylic acid potassium salt
γ-irradiated
Synonym(s):
Poly (I:C), Poly(I) • Poly(C)
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About This Item
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This Item | P9582 | P4154 | P1530 |
|---|---|---|---|
| assay ≥99% (TLC) | assay ≥99% (less than 1% free nucleotides, TLC) | assay ≥98% (TLC) | assay ≥99% (less than 1% free nucleotides, TLC) |
| Quality Level 200 | Quality Level 300 | Quality Level 200 | Quality Level 300 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| composition , 8-12% UV | composition Poly(I) • Poly(C), 10% (balance buffer salts as sodium chloride and sodium phosphate) | composition - | composition - |
Biochem/physiol Actions
Transfection of Poly (I:C) into NIT-1 cells has been used as a model of intracellular dsRNA-induced β cell apoptosis. Eighteen hours post transfection, 45% of the cells were apoptotic with an increase in NF-kB, p50/p65 nuclear translocation, and cleavage of caspases 3 and 8, as well as transcriptional induction of caspase 12, Fas, IL-15, and the TNF receptor-associated ligand (TRAIL). It has been suggested that Poly(I:C) is one of the most appropriate generators of stable mature dendritic cells (DC). These mature DC might generate in vivo effective immune responses after injection due to their ability to secrete bioactive IL-12 after CD40 ligation. Poly (I:C) was used as a potent adjuvant to enhance the specific anti-tumor immune responses against a peptide-based vaccine.
Packaging
Package size based on polynucleotide content
Other Notes
Double-stranded homopolymer.
Physical form
10% Poly (I:C) with sodium chloride and sodium phosphate buffer salts
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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