K1388

KT5823

≥85% (HPLC), lyophilized powder

• Empirical Formula (Hill Notation): C₂₉H₂₅N₃O₅
• CAS Number: 126643-37-6
• Molecular Weight: 495.53
• MDL number: MFCD09878278
• UNSPSC Code: 12352200
• PubChem Substance ID: 24896206
• NACRES: NA.77

Properties

• Product Name: KT 5823, ≥85% (HPLC), lyophilized powder
• Quality Level: 100
• assay: ≥85% (HPLC)
• form: lyophilized powder
• color: white
• solubility: ethyl acetate: 5 mg/mL
• storage temp.: 2-8°C
• SMILES string: COC(=O)[C@]1(CC2O[C@]1(C)n3c4ccccc4c5c6CN(C)C(=O)c6c7c8ccccc8n2c7c35)OC
• InChI: 1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1
• InChI key: QTYMDECKVKSGSM-YMUMJAELSA-N

Description

General description

KT5823 is a protein kinase inhibitor. It inhibits guanosine monophosphate (GMP)-dependent protein kinase activity (cGK). It is a staurosporine compound, which promotes the thyroid-stimulating hormone and regulates Na⁺/I⁻ symporter (NIS) expression.

Application

KT 5823 has been used as cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) inhibitor in cortical cultures, cortical neurons and in mouse brain capillary endothelial cells.

Biochem/physiol Actions

Selective inhibitor of PKG.

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)