L1290

Lactoferricin B, fragment 4-14 trifluoroacetate salt

≥95% (HPLC)

• Synonym(s): bLFC (26-36), bovine lactoferricin
• Empirical Formula (Hill Notation): C₇₀H₁₁₃N₂₅O₁₃S
• Molecular Weight: 1544.87
• MDL number: MFCD04040902
• UNSPSC Code: 12352202
• NACRES: NA.32

Properties

• Quality Level: 200
• assay: ≥95% (HPLC)
• solubility: H₂O: soluble
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria
• mode of action: cell membrane | interferes
• storage temp.: −20°C

Description

Amino Acid Sequence

Arg-Arg-Trp-Gln-Trp-Arg-Met-Lys-Lys-Leu-Gly

General description

Chemical structure: peptide

Application

Lactoferricin B, fragment 4-14 trifluoroacetate salt has been used to study effect of lactoferricin on cell proliferation of human colon cancer cells. It has been used in study of ultraviolet light-mediated DNA damage in human colon cancer cells.

Biochem/physiol Actions

Antibiotic peptide in colostrum and milk that protects from bacterial infection at mucosal surfaces.

Lactoferricin B also suppresses liver and lung metastasis in murine melanomas and lymphomas. In addition, it causes cell death in human leukemic and carcinoma cell lines. It is effective against Escherichia coli, Salmonella enteritidis, Klebsiella pneumoniae, Proteus vulgaris, Yersinia enterocolitica, Pseudomonas aeruginosa, Campylobacter jejuni, Staphylococcus aureus, Streptococcus mutans, Corynebacterium diphtheriae, Listeria monocytogenes and Clostridium perfringens.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)