M0194
Anti-Muscarinic Acetylcholine Receptor (M3) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Synonym(s):
Muscarinic Acetylcholine Receptor M3 Antibody, Muscarinic Acetylcholine Receptor M3 Antibody - Anti-Muscarinic Acetylcholine Receptor (M3) antibody produced in rabbit
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About This Item
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This Item | M9808 | WH0001129M1 | HPA013172 |
|---|---|---|---|
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| biological source rabbit | biological source rabbit | biological source mouse | biological source rabbit |
| antibody form affinity isolated antibody | antibody form affinity isolated antibody | antibody form purified immunoglobulin | antibody form affinity isolated antibody |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| shipped in dry ice | shipped in - | shipped in dry ice | shipped in wet ice |
| clone polyclonal | clone polyclonal | clone 4B5, monoclonal | clone polyclonal |
General description
Cholinergic receptor muscarinic 3 (CHRM3) gene is located on the human chromosome at 1q43 and encodes for the M3 subtype of muscarinic acetylcholine (ACh) receptors. Muscarinic receptor 3 (M3R) is one of the five muscarinic receptors (M1R-M5R). It is a member of the class A family of G-protein coupled receptors (GPCRs). M3R is localized to the salivary glands, lachrymal glands, trachea and bronchi.
Specificity
Rabbit polyclonal anti-Muscarinic Acetylcholine Receptor (M3) antibody recognizes rat, human, mouse Muscarinic Acetylcholine Receptor (M3).
Immunogen
synthetic peptide corresponding to amino acid residues 461-479 of the third intracellular loop of rat muscarinic acetylcholine receptor M3. This sequence is identical in human, mouse, pig, and bovine.
Application
Anti-Muscarinic Acetylcholine Receptor (M3) antibody produced in rabbit has been used in immunohistochemistry and western blotting.
Rabbit polyclonal anti-Muscarinic Acetylcholine Receptor (M3) antibody is used to tag muscarinic acetylcholine receptor (M3) for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of muscarinic acetylcholine receptor (M3) in information processing and plastic changes in CNS function.
Biochem/physiol Actions
Muscarinic receptor 3 (M3R) is involved in the contraction of the detrusor muscle. It is also involved in the secretion of saliva and bladder contraction. It participates in several pathological processes of lung disease, such as chronic obstructive pulmonary disease (COPD). Mutations in the CHRM3 gene is associated with congenital bladder malformations related to prune-belly-like syndrome (PBS).
Physical form
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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