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M1022

Sigma-Aldrich

Dihydrocapsaicin

from Capsicum sp., ≥85% (HPLC), powder, VR1 vanilloid receptor agonist

Synonym(s):

6,7-Dihydrocapsaicin, 8-Methyl-N-vanillylnonanamide, N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methylnonenamide

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About This Item

Empirical Formula (Hill Notation):
C18H29NO3
CAS Number:
Molecular Weight:
307.43
Beilstein/REAXYS Number:
2815150
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Pricing and availability is not currently available.

Product Name

Dihydrocapsaicin, from Capsicum sp., ≥85%

biological source

Capsicum sp.

Quality Level

assay

≥85%

storage temp.

2-8°C

SMILES string

COc1cc(CNC(=O)CCCCCCC(C)C)ccc1O

InChI

1S/C18H29NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h10-12,14,20H,4-9,13H2,1-3H3,(H,19,21)

InChI key

XJQPQKLURWNAAH-UHFFFAOYSA-N

Gene Information

human ... TRPV1(7442)
rat ... Trpv4(66026)

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This Item
Z743264Z743263Z743261
packaging

pack of 1 ea

packaging

pack of 1 ea

packaging

pack of 1 ea

packaging

pack of 1 ea

manufacturer/tradename

Julabo 8930410

manufacturer/tradename

Julabo 8930413

manufacturer/tradename

Julabo 8930412

manufacturer/tradename

Julabo 8930425

I.D. × L

14 mm × 1 m , for use with 8-10 mm I.D. reinforced tubing

I.D. × L

23 mm × 1 m , for use with 1/2 inch I.D. reinforced tubing

I.D. × L

18 mm × 1 m , for use with 12 mm I.D. reinforced tubing

I.D. × L

35 mm × 1 m , for use with 1 inch I.D. reinforced tubing

Application

Dihydrocapsaicin has been used:
  • as a standard to analyze the level of dihydrocapsaicin in endogenous An2 and capsaicin synthase silenced fruits[1]
  • as an external standard to determine the variability in capsaicinoid content in different landraces of capsicum[2]
  • in the activation or ablation of capsaicin-sensitive primary afferents (CSPA) fibres[3]

Biochem/physiol Actions

Dihydrocapsaicin/8-methyl-N-vanillylnonanamide; N-[−4-hydroxy-3-methoxybenzyl] 8-methylnonanamide (DHC) is an active component of capsaicinoids in chili peppers.[4] DHC is capable of reducing body temperature. Hence it is considered as a pharmaceutical-induced hypothermia (PIH) candidate to treat cardiac arrest (CA) patients.[5] It may possess anti-cancer, anti-inflammation, antioxidant, anti-obesity properties. DHC might help in the reduction of oxidative stress and inflammation in ischemia and reperfusion (I/R) injury. DHC can repress nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway.[4]
VR1 vanilloid receptor agonist.

Linkage

Capsaicin analog.

pictograms

Skull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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